Acyclovir and Merrem drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Acyclovir (acyclovir) and Merrem (meropenem). Common drug interactions include dyspnoea among females and rash maculo-papular among males.
The phase IV clinical study analyzes what interactions people have when they take Acyclovir and Merrem. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.
What is Acyclovir?
Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.
What is Merrem?
Merrem has active ingredients of meropenem. eHealthMe is studying from 996 Merrem users. Check the latest studies of Merrem.
27 people who take Acyclovir and Merrem together, and have interactions are studied.

What are the common drug interactions of Acyclovir and Merrem, by gender? *:
female:
- Dyspnoea (difficult or laboured respiration)
- Electrocardiogram qt prolonged
- Febrile neutropenia (fever with reduced white blood cells)
- Fungal infection
- Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
- General physical health deterioration (weak health status)
- Hyperlipidaemia (presence of excess lipids in the blood)
- Hyperosmolar state (life-threatening emergency manifested by marked elevation of blood glucose)
- Hypertension (high blood pressure)
- Hypotension (abnormally low blood pressure)
male:
- Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
- Aortic arteriosclerosis (hardening of the aortic arteries)
- Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)
- Respiratory distress (difficulty in breathing)
- White blood cell count decreased
- Abdominal pain
- Abdominal pain upper
- Acidosis (build-up of carbon dioxide in the blood)
- Anaemia (lack of blood)
- Asthenia (weakness)
What are the common drug interactions of Acyclovir and Merrem, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Anaemia (lack of blood)
- Delayed engraftment
- Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
- Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
10-19:
- Blood amylase increased
- Lipase increased
- Pancreatitis (inflammation of pancreas)
20-29:
n/a
30-39:
- Blood amylase increased
- Lipase increased
40-49:
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
- Blood magnesium decreased
- Blood potassium decreased
- Cardiac arrest
- Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
- Electrocardiogram qt prolonged
- Haemoglobin decreased
- Neutropenia (an abnormally low number of neutrophils)
- Neutrophilia
- Red blood cell abnormality (abnormal red blood cells)
50-59:
- Pyrexia (fever)
- Rash erythematous (redness of the skin)
- Sepsis syndrome (a clinical condition of blood infection)
- Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
- Skin exfoliation (removal of the oldest dead skin cells)
- Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
- Unresponsive to stimuli
- Vomiting
- Wheezing (a high-pitched whistling sound made while you breath)
- White blood cell count decreased
60+:
- Hypoxia (low oxygen in tissues)
- Platelet count decreased
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Dyspnoea (difficult or laboured respiration)
- Haemoglobin decreased
- Haemorrhage intracranial (bleeding within the skull)
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
- Multi-organ failure (multisystem organ failure)
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Pneumonia
What are the existing conditions these people have? *
- Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 14.81%
- Encephalitis (inflammation of the brain): 3 people, 11.11%
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 11.11%
* Approximation only. Some reports may have incomplete information.
Do you take Acyclovir and Merrem?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Acyclovir and Merrem:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Acyclovir:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Merrem:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Acyclovir and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Merrem and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
- Erden M, Gulcan E, Bilen A, Bilen Y, Uyanik A, Keles M, "Pancytopen? a and Seps? s due to Meropenem: A Case Report", Tropical Journal of Pharmaceutical Research, 2013 Jan .
- Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
- Erden M, Gulcan E, Bilen A, Bilen Y, Uyanik A, Keles M, "Pancytopen? a and Seps? s due to Meropenem: A Case Report", Tropical Journal of Pharmaceutical Research, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on acyclovir and meropenem (the active ingredients of Acyclovir and Merrem, respectively), and Acyclovir and Merrem (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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