Fycompa and Divalproex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fycompa (perampanel) and Divalproex (divalproex sodium). Common drug interactions include balance disorder among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Fycompa and Divalproex. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Fycompa?

Fycompa has active ingredients of perampanel. eHealthMe is studying from 4,387 Fycompa users. Check the latest studies of Fycompa.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

On Aug, 05, 2026

38 people who take Fycompa and Divalproex together, and have interactions are studied.

Fycompa and Divalproex drug interactions.

What are the common drug interactions of Fycompa and Divalproex, by gender? *:

female:

Balance disorder
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Aggression
Memory impairment
Suicidal ideation
Abnormal behaviour
Anger
Breast cancer
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Aggression
Ear pain
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypersomnia (excessive daytime sleepiness (eds))
Joint swelling
Memory impairment
Nausea (feeling of having an urge to vomit)
Overdose

What are the common drug interactions of Fycompa and Divalproex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Agitation (state of anxiety or nervous excitement)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

10-19:

Death
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

Diarrhoea
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hypersomnia (excessive daytime sleepiness (eds))
Nausea (feeling of having an urge to vomit)
Poor venous access
Somnolence (a state of near-sleep, a strong desire for sleep)
Viral infection
Vitamin d deficiency
Vomiting
Weight decreased

30-39:

Suicidal ideation
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Aggression
Anger
Contusion (a type of hematoma of tissue in which capillaries)
Depression
Dizziness
Gait disturbance
Headache (pain in head)
Homicidal ideation (thoughts about human killing another human)

40-49:

Drug withdrawal convulsions
Ear pain
Fall
Memory impairment
Overdose
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Temporal lobe epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe)

50-59:

Aggression
Fall
Limb injury
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Coma (state of unconsciousness lasting more than six hours)
Dissociation
Balance disorder
Fatigue (feeling of tiredness)
Nipple pain
Postmenopausal haemorrhage (post-menopausal bleeding)

60+:

Balance disorder
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Calcinosis (calcium deposits in any soft tissue)
Drug hypersensitivity
Joint swelling
Peripheral swelling
Pneumonia
Pulmonary oedema (fluid accumulation in the lungs)
Breast cancer

What are the existing conditions these people have? *

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 19 people, 50.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 9 people, 23.68%
Partial Seizures (seizures which affect only a part of the brain at onset): 4 people, 10.53%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 7.89%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 3 people, 7.89%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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