Aczone and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aczone (dapsone) and Profen (ibuprofen). Common drug interactions include blood pressure increased among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Aczone and Profen. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Aczone?

Aczone has active ingredients of dapsone. It is often used in acne. eHealthMe is studying from 1,152 Aczone users. Check the latest studies of Aczone.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

49 people who take Aczone and Profen together, and have interactions are studied.

What are the common drug interactions of Aczone and Profen, by gender? *:

female:

Blood pressure increased
Drug ineffective
Fatigue (feeling of tiredness)
Inflammation
Insomnia (sleeplessness)
Nightmare (unpleasant dream)
Victim of abuse
Vitamin d decreased
Hypersensitivity
Kidney infection

male:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Scar
Disability
Eye irritation
Nephrolithiasis (calculi in the kidneys)
Blood cholesterol increased
Blood creatine phosphokinase increased
Blood triglycerides increased
Dermal cyst

What are the common drug interactions of Aczone and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anaphylactic reaction (serious allergic reaction)
Hypersensitivity
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Papilloedema (optic disc swelling)
Photophobia (extreme sensitivity to light)
Vision blurred

20-29:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood cholesterol increased
Blood creatine phosphokinase increased
Blood pressure increased
Blood triglycerides increased
Dermal cyst
Eosinophil count increased
Nodule (a growth of abnormal tissue)
Papule

30-39:

Tardive dyskinesia (a disorder that involves involuntary movements)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Breast fibroma (fibroadenomas of the breast are small, solid, rubbery, noncancerous, harmless lumps composed of fibrous and glandular tissue)
Bruxism (habitual grinding of the teeth, typically during sleep)
Dry mouth
Ear infection
Eye irritation
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

40-49:

Insomnia (sleeplessness)
Nightmare (unpleasant dream)
Victim of abuse
Vitamin d decreased
Depression
Eye infection
Hellp syndrome (life-threatening pregnancy complication)
Influenza
Migraine (headache)
Pneumonia

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Fall
Foot fracture
Joint stiffness
Mycobacterium tuberculosis complex test positive
Wheezing (a high-pitched whistling sound made while you breath)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 37 people, 75.51%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 24 people, 48.98%

* Approximation only. Some reports may have incomplete information.

Do you take Aczone and Profen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously