Adalat cc and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adalat cc (nifedipine) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include renal failure among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Adalat cc and Benadryl. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Adalat cc?

Adalat cc has active ingredients of nifedipine. It is often used in high blood pressure. eHealthMe is studying from 5,019 Adalat cc users. Check the latest studies of Adalat cc.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 06, 2026

28 people who take Adalat cc and Benadryl together, and have interactions are studied.

Adalat cc and Benadryl drug interactions.

What are the common drug interactions of Adalat Cc and Benadryl, by gender? *:

female:

Renal failure (kidney dysfunction)
Therapeutic response unexpected
Arthropathy
Blood cholesterol increased
Contusion (a type of hematoma of tissue in which capillaries)
Cyst (a closed sac)
Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Gastroenteritis (inflammation of stomach and intestine)
Ill-defined disorder

male:

Pneumonia
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hepatitis (inflammation of the liver)
Hepatocellular damage (liver damage)
Hepatomegaly (abnormal enlargement of the liver)
Hyperkalaemia (damage to or disease of the kidney)
Hyperlipidaemia (presence of excess lipids in the blood)
Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Renal failure acute (rapid kidney dysfunction)

What are the common drug interactions of Adalat Cc and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block complete (heart block complete)
Blood triglycerides increased
Bradycardia (abnormally slow heart action)
Cardiac arrest
Cardiogenic shock (inadequate circulation of blood)
Electrocardiogram qt prolonged
Hepatic steatosis (fatty liver disease)
Hepatitis (inflammation of the liver)
Hepatocellular damage (liver damage)

40-49:

Peripheral swelling
Sinusitis (inflammation of sinus)
Skin discolouration (change of skin colour)
Tremor (trembling or shaking movements in one or more parts of your body)
Urticaria (rash of round, red welts on the skin that itch intensely)
Uterine prolapse
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Disability
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

50-59:

Pain
Headache (pain in head)
Nasopharyngitis (inflammation of the nasopharynx)
Abdominal discomfort
Abdominal pain
Asthenia (weakness)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Decreased appetite
Diarrhoea
Drug ineffective

60+:

Chronic kidney disease
Loss of consciousness
Blood lactate dehydrogenase increased
Blood urea increased
Duodenitis (inflammation of the duodenum)
Gamma-glutamyltransferase increased
Injection site pain
Leukocytosis (increased white blood cells)
Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood)
Mucosal erosion (peeling off of mucous membrane)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 25.00%
High Blood Cholesterol: 5 people, 17.86%
Depression: 5 people, 17.86%
Nausea (feeling of having an urge to vomit): 4 people, 14.29%
Stress And Anxiety: 4 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 14.29%
Pancreatic Neuroendocrine Tumor Metastatic: 4 people, 14.29%
Neoplasm Malignant (cancer tumour): 4 people, 14.29%
Infusion Related Reaction: 3 people, 10.71%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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