Adcirca and Blopress drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adcirca (tadalafil) and Blopress (candesartan cilexetil). Common drug interactions include gamma-glutamyltransferase increased among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Adcirca and Blopress. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

What is Blopress?

Blopress has active ingredients of candesartan cilexetil. It is often used in high blood pressure. eHealthMe is studying from 7,479 Blopress users. Check the latest studies of Blopress.

On Aug, 12, 2026

23 people who take Adcirca and Blopress together, and have interactions are studied.

What are the common drug interactions of Adcirca and Blopress, by gender? *:

female:

Gamma-glutamyltransferase increased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood lactate dehydrogenase increased
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Hypokalaemia (low potassium)
Liver disorder (liver diseases)
Anaemia (lack of blood)
Pyrexia (fever)
Rhinitis allergic (inflammation of the nasal airways due to allergy)

male:

Diarrhoea
Headache (pain in head)
Nasopharyngitis (inflammation of the nasopharynx)
Ascites (accumulation of fluid in the abdominal cavity)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site induration
Infusion site pain
Weight decreased
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

What are the common drug interactions of Adcirca and Blopress, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Diarrhoea
Headache (pain in head)

20-29:

n/a

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood lactate dehydrogenase increased
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Gamma-glutamyltransferase increased
Hypokalaemia (low potassium)
Liver disorder (liver diseases)
Anaemia (lack of blood)
Pyrexia (fever)
Rhinitis allergic (inflammation of the nasal airways due to allergy)

40-49:

Diarrhoea
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pain
Pain in extremity
Pain in jaw
Plantar fasciitis (painful inflammatory process of the plantar fascia)
Pneumonia
Rash
Stomatitis (inflammation of mucous membrane of mouth)

50-59:

Cardiac failure
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Nasopharyngitis (inflammation of the nasopharynx)
Right ventricular failure (right half of the heart fails to work)
Uterine cancer
Uterine haemorrhage (uterine bleeding)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)

60+:

Diarrhoea
Ascites (accumulation of fluid in the abdominal cavity)
Intraductal papillary mucinous neoplasm (tumour (neoplasm) that grows within the pancreatic ducts)
Pancreatic enlargement
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Puncture site pain
Skin mass
White blood cell count decreased
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Hypoproteinaemia (too little prolactin circulating in the blood)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 20 people, 86.96%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 7 people, 30.43%
Stomatitis (inflammation of mucous membrane of mouth): 5 people, 21.74%
Rashes (redness): 5 people, 21.74%
Nausea (feeling of having an urge to vomit): 5 people, 21.74%
Nasopharyngitis (inflammation of the nasopharynx): 5 people, 21.74%
Headache (pain in head): 5 people, 21.74%
Muscle Aches (muscle pain): 4 people, 17.39%
Gastric Ulcer (stomach ulcer): 4 people, 17.39%
Diarrhea: 4 people, 17.39%

* Approximation only. Some reports may have incomplete information.

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