Adcirca and Glucophage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adcirca (tadalafil) and Glucophage (metformin hydrochloride). Common drug interactions include fatigue among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Adcirca and Glucophage. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

On Jul, 12, 2026

56 people who take Adcirca and Glucophage together, and have interactions are studied.

Adcirca and Glucophage drug interactions.

What are the common drug interactions of Adcirca and Glucophage, by gender? *:

female:

Fatigue (feeling of tiredness)
Hypoxia (low oxygen in tissues)
Influenza
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose fluctuation
Chills (felling of cold)
Ear pain
Epistaxis (bleed from the nose)
Lacrimation increased
Rhinorrhoea (watery mucus discharge from the nose)

male:

Dyspnoea (difficult or laboured respiration)
Cardiac failure
Sepsis (a severe blood infection that can lead to organ failure and death)
Anaemia (lack of blood)
Brain natriuretic peptide increased
Decreased appetite
Hypotension (abnormally low blood pressure)
Muscle spasms (muscle contraction)
Renal failure (kidney dysfunction)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Adcirca and Glucophage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dizziness
Infusion site cellulitis
Infusion site haemorrhage (bleeding from infusion site)
Infusion site infection
Infusion site pain
Puncture site discharge

40-49:

Death

50-59:

Hepatomegaly (abnormal enlargement of the liver)
Influenza
Nasopharyngitis (inflammation of the nasopharynx)
Oedema peripheral (superficial swelling)
Oropharyngeal pain
Toothache (tooth pain)
Wheezing (a high-pitched whistling sound made while you breath)
Brain natriuretic peptide increased
Cellulitis (infection under the skin)
Dizziness

60+:

Headache (pain in head)
Dizziness
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Right ventricular failure (right half of the heart fails to work)
Cardiac failure
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Sepsis (a severe blood infection that can lead to organ failure and death)
Diarrhoea
Oedema (fluid collection in tissue)
Orthopnoea (shortness of breath (dyspnea) when lying down)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 38 people, 67.86%
Type 2 Diabetes: 5 people, 8.93%
Pain: 5 people, 8.93%
Dyspnea (difficult or laboured breathing): 4 people, 7.14%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 3 people, 5.36%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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