Adderall 5 and Lyrica drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall 5 (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Lyrica (pregabalin). Common drug interactions include cognitive disorder among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall 5 and Lyrica. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall 5?

Adderall 5 has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 2,997 Adderall 5 users. Check the latest studies of Adderall 5.

What is Lyrica?

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 261,646 Lyrica users. Check the latest studies of Lyrica.

On Jul, 10, 2026

34 people who take Adderall 5 and Lyrica together, and have interactions are studied.

Adderall 5 and Lyrica drug interactions.

What are the common drug interactions of Adderall 5 and Lyrica, by gender? *:

female:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Colitis (inflammation of colon)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Death
Deformity (disfigurement)
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diplopia (double vision)
Discomfort
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

male:

Fatigue (feeling of tiredness)
Contusion (a type of hematoma of tissue in which capillaries)
Drug administration error
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Empyema (collection of pus in a cavity in the body)
Impaired healing
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Neck pain
Pain in extremity

What are the common drug interactions of Adderall 5 and Lyrica, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Back pain
Calculus ureteric (stone in ureter)
Cholecystitis chronic (long lasting infection of gallbladder)
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gallbladder injury
Haematemesis (vomiting of blood)
Hydronephrosis (water inside the kidney)

20-29:

Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Back pain
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Fatigue (feeling of tiredness)
Fear
Injection site erythema (redness at injection site)
Nervousness
Panic disorder
Pruritus (severe itching of the skin)

30-39:

Fatigue (feeling of tiredness)
Affect lability (emotional incontinence)
Agitation (state of anxiety or nervous excitement)
Irritability
Memory impairment
Weight increased
Back pain
Complex partial seizures (epileptic seizure)
Gait disturbance
Gastric ulcer haemorrhage (bleeding ulcer of stomach)

40-49:

Oestrogen receptor assay positive
Pneumonia
Rash pruritic (redness with itching)
Respiratory failure (inadequate gas exchange by the respiratory system)
Brain neoplasm (tumour of brain)
Drug ineffective
Memory impairment
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to lung (cancer spreads to lung)
Tardive dyskinesia (a disorder that involves involuntary movements)

50-59:

Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Abdominal hernia
Emotional disorder
Pancreatitis acute (sudden inflammation of pancreas)
Pleural effusion (water on the lungs)
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Respiratory failure (inadequate gas exchange by the respiratory system)
Skeletal injury (bone and supporting muscle injury)
Tension (the act or process of stretching something tight)

60+:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dysphagia (a condition in which swallowing is difficult or painful)
Empyema (collection of pus in a cavity in the body)
Impaired healing
Pneumonia

What are the existing conditions these people have? *

Pain: 9 people, 26.47%
Stress And Anxiety: 7 people, 20.59%
Sleep Disorder: 4 people, 11.76%
Muscle Spasms (muscle contraction): 3 people, 8.82%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 3 people, 8.82%
High Blood Pressure: 3 people, 8.82%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 5.88%
Osteoporosis (bones weak and more likely to break): 2 people, 5.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.88%
Headache (pain in head): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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