Adderall xr 10 and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall xr 10 (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Methotrexate (methotrexate sodium). Common drug interactions include pyrexia among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall xr 10 and Methotrexate. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall xr 10?

Adderall xr 10 has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,274 Adderall xr 10 users. Check the latest studies of Adderall xr 10.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 06, 2026

18 people who take Adderall xr 10 and Methotrexate together, and have interactions are studied.

Adderall xr 10 and Methotrexate drug interactions.

What are the common drug interactions of Adderall Xr 10 and Methotrexate, by gender? *:

female:

Pyrexia (fever)
Injection site haematoma (localized swelling filled with blood at injection site)
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Injection site pain
Malaise (a feeling of general discomfort or uneasiness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Throat irritation
Activities of daily living impaired
Arthralgia (joint pain)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)

male:

Anxiety
B-cell lymphoma (blood cancer affecting b cells)
Reflux oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Upper respiratory tract infection
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)
Bipolar disorder (mood disorder)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Suicidal ideation
Anger

What are the common drug interactions of Adderall Xr 10 and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anxiety
B-cell lymphoma (blood cancer affecting b cells)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Conjunctivitis (pink eye)
Cough
Ear infection
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema eyelids (patches of skin become rough and inflamed, with itching and bleeding blisters on eyelid)
Lung neoplasm (tumour of lung)
Pyrexia (fever)

10-19:

Arthralgia (joint pain)
Injection site erythema (redness at injection site)
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Painful respiration

20-29:

Pyrexia (fever)
Malaise (a feeling of general discomfort or uneasiness)
Throat irritation
Activities of daily living impaired
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood glucose increased
Blood triglycerides increased
Chills (felling of cold)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cough

30-39:

Visual impairment
Hypoaesthesia (reduced sense of touch or sensation)
Injection site pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pyrexia (fever)
Sinusitis (inflammation of sinus)
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

n/a

50-59:

Exposure to communicable disease
Headache (pain in head)
Injection site haematoma (localized swelling filled with blood at injection site)

60+:

Local swelling (swelling at the site of some application of substance or injury)

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 8 people, 44.44%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 11.11%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 11.11%
Depression: 2 people, 11.11%
Systemic Sclerosis (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 1 person, 5.56%
Gastrointestinal Inflammation (inflammation of stomach and intestine): 1 person, 5.56%
Acne (skin problems that cause pimples): 1 person, 5.56%
Bipolar Disorder (mood disorder): 1 person, 5.56%
Birth Control: 1 person, 5.56%
Chronic Fatigue Syndrome (disorder that causes extreme fatigue): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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