Adderall and Primrose oil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Primrose oil (evening primrose oil). Common drug interactions include menorrhagia among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall and Primrose oil. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.

What is Primrose oil?

Primrose oil has active ingredients of evening primrose oil. eHealthMe is studying from 1,849 Primrose oil users. Check the latest studies of Primrose oil.

On Jul, 21, 2026

43 people who take Adderall and Primrose oil together, and have interactions are studied.

Adderall and Primrose oil drug interactions.

What are the common drug interactions of Adderall and Primrose Oil, by gender? *:

female:

Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Nephrolithiasis (calculi in the kidneys)
Muscle spasms (muscle contraction)
Drug ineffective
Back pain
Injection site erythema (redness at injection site)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

male:

Abdominal pain upper
Agitation (state of anxiety or nervous excitement)
Intermittent explosive disorder (behavioural disorder characterized by extreme expressions of anger)
Sleep terror (felling of terror in sleep)

What are the common drug interactions of Adderall and Primrose Oil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Agitation (state of anxiety or nervous excitement)
Intermittent explosive disorder (behavioural disorder characterized by extreme expressions of anger)

20-29:

n/a

30-39:

Back disorder
Disease recurrence
Drug hypersensitivity
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hysterectomy
Malignant melanoma (skin cancer rises from melancytes)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

40-49:

Abdominal distension
Abdominal pain
Device dislocation
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)

50-59:

Muscle spasms (muscle contraction)
Swelling
Urinary tract infection
Abdominal discomfort
Anxiety
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Depressed mood
Diarrhoea
Fatigue (feeling of tiredness)
Headache (pain in head)

60+:

Drug ineffective
Pancreatitis (inflammation of pancreas)
Fracture nonunion (permanent failure of healing following a broken bone)
Hip fracture
Hypoaesthesia (reduced sense of touch or sensation)
Ilium fracture
Joint range of motion decreased (disease of joint movement)
Lower limb fracture
Multiple fractures
Muscle spasms (muscle contraction)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 51.16%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 16 people, 37.21%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 23.26%
Pain: 4 people, 9.30%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.98%
Migraine Without Aura (headache without neurological problems): 3 people, 6.98%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 6.98%
High Blood Pressure: 3 people, 6.98%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.98%
Gait Disturbance: 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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