Adderall and Pyridoxine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Pyridoxine (pyridoxine (vitamin b6)). Common drug interactions include anxiety among females and craniocerebral injury among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall and Pyridoxine. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.

What is Pyridoxine?

Pyridoxine has active ingredients of pyridoxine (vitamin b6). eHealthMe is studying from 8,747 Pyridoxine users. Check the latest studies of Pyridoxine.

On Jul, 10, 2026

67 people who take Adderall and Pyridoxine together, and have interactions are studied.

Adderall and Pyridoxine drug interactions.

What are the common drug interactions of Adderall and Pyridoxine, by gender? *:

female:

Anxiety
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Staphylococcal infection (an infection with staphylococcus bacteria)
Dyspnoea (difficult or laboured respiration)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Pneumonia
Drug ineffective
Oedema (fluid collection in tissue)
Pain

male:

Craniocerebral injury (injury to cranium and brain)
Fall
Hospitalisation
Hunger
Iron deficiency anaemia
Palpitations (feelings or sensations that your heart is pounding or racing)
Parasomnia (sleep disorders that involve abnormal and unnatural movements, behaviours, emotions, perceptions)
Restlessness (not able to rest)
Colitis ulcerative (inflammation of colon with ulcer)
Thrombolysis (resolving the blood clot)

What are the common drug interactions of Adderall and Pyridoxine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Thrombolysis (resolving the blood clot)
Weight decreased
Craniocerebral injury (injury to cranium and brain)
Fall
Thoracic outlet syndrome (pain in the arm, shoulder, and neck. it happens when the nerves or blood vessels just below your neck are compressed)

30-39:

Agitation (state of anxiety or nervous excitement)
Arrhythmia (irregular heartbeat)
Blood cholesterol increased
Cardiac disorder
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Device related infection
Gallbladder operation
Hepatic enzyme increased
Iron deficiency anaemia
Migraine (headache)

40-49:

Neuropathy peripheral (surface nerve damage)
Asthma
Essential tremor
Pneumonia
Weight decreased
Abdominal distension
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Blood pressure increased

50-59:

Anxiety
Back pain
Bladder disorder
Dyspnoea (difficult or laboured respiration)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Obesity (having too much body fat)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Renal disorder (kidney disease)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Burning sensation

60+:

Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Dyskinesia (abnormality or impairment of voluntary movement)
Crying
Drug hypersensitivity
General physical health deterioration (weak health status)
Hypertension (high blood pressure)
Influenza like illness
Pain
Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery)
Quality of life decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 57 people, 85.07%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 39 people, 58.21%
Drowsiness: 11 people, 16.42%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.46%
Neuropathy Peripheral (surface nerve damage): 4 people, 5.97%
Intervertebral Disc Degeneration (spinal disc degeneration): 4 people, 5.97%
Depression: 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

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