Adderall and Sodium bicarbonate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Sodium bicarbonate (sodium bicarbonate). Common drug interactions include nausea among females and blood urine present among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall and Sodium bicarbonate. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,226 Adderall users. Check the latest studies of Adderall.

What is Sodium bicarbonate?

Sodium bicarbonate has active ingredients of sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 27,283 Sodium bicarbonate users. Check the latest studies of Sodium bicarbonate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

39 people who take Adderall and Sodium bicarbonate together, and have interactions are studied.

Adderall and Sodium bicarbonate drug interactions.

What are the common drug interactions of Adderall and Sodium Bicarbonate, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Therapeutic response unexpected
Hypotension (abnormally low blood pressure)
Dizziness
Fall
Contusion (a type of hematoma of tissue in which capillaries)
Ear infection
Gastrointestinal pain
Heart rate increased
Loss of consciousness

male:

Blood urine present
Chronic kidney disease
Lip haemorrhage (bleeding lip)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nephropathy (damage to or disease of a kidney)
Oedema peripheral (superficial swelling)
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the common drug interactions of Adderall and Sodium Bicarbonate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Bladder pain
Contusion (a type of hematoma of tissue in which capillaries)
Haemorrhagic diathesis (bleeding tendency)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

20-29:

Blood glucose increased
Blood magnesium decreased
Dehydration (dryness resulting from the removal of water)
Hypotension (abnormally low blood pressure)
Renal failure (kidney dysfunction)
Renal pain (kidney pain)

30-39:

Blood urine present
Constipation
Diarrhoea
Haematochezia (passage of stools containing blood)
Intestinal polyp (small growths in the bowel with the potential for further growth)
Nasopharyngitis (inflammation of the nasopharynx)
Retinal vasculitis (a sight-threatening inflammatory eye condition that involves the retinal vessels)
Visual impairment
Fatigue (feeling of tiredness)
Lymphoedema (localized fluid retention and tissue swelling)

40-49:

Fall
Asthenia (weakness)
Chronic kidney disease
Deafness
Dizziness
Ear infection
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

Abdominal pain
Breast mass
Bronchial hyperreactivity
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dizziness
Dyspnoea (difficult or laboured respiration)
Ear infection
Injury
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)

60+:

Back pain
Blood potassium decreased
Nephropathy (damage to or disease of a kidney)
Oedema peripheral (superficial swelling)
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Diarrhoea
Flatulence (flatus expelled through the anus)
Hospitalisation

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 20.51%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 20.51%
Pain: 6 people, 15.38%
High Blood Pressure: 5 people, 12.82%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 10.26%
Drowsiness: 4 people, 10.26%
High Blood Cholesterol: 4 people, 10.26%
Hypotension (abnormally low blood pressure): 3 people, 7.69%
Type 1 Diabetes: 3 people, 7.69%
Cardiac Disorder: 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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