Adderall and Tylenol w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Tylenol w/ codeine (acetaminophen; codeine phosphate). Common drug interactions include head injury among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Adderall and Tylenol w/ codeine. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,226 Adderall users. Check the latest studies of Adderall.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

30 people who take Adderall and Tylenol w/ codeine together, and have interactions are studied.

Adderall and Tylenol w/ codeine drug interactions.

What are the common drug interactions of Adderall and Tylenol W/ Codeine, by gender? *:

female:

Head injury
Heart injury
Hepatic steatosis (fatty liver disease)
Hot flush (sudden feelings of heat)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Injection site pain

male:

Pyrexia (fever)
Anxiety
Reflux oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Upper respiratory tract infection
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)
Bipolar disorder (mood disorder)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Suicidal ideation
Anger

What are the common drug interactions of Adderall and Tylenol W/ Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anxiety
B-cell lymphoma (blood cancer affecting b cells)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Conjunctivitis (pink eye)
Cough
Ear infection
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema eyelids (patches of skin become rough and inflamed, with itching and bleeding blisters on eyelid)
Lung neoplasm (tumour of lung)
Pyrexia (fever)

10-19:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Arthralgia (joint pain)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Chills (felling of cold)
Cholecystitis (infection of gallbladder)
Cystitis (inflammation of the wall of the bladder)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Gastric disorder (disease of stomach)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

20-29:

Drug addiction
Self-injurious ideation

30-39:

n/a

40-49:

Anxiety
Colitis ulcerative (inflammation of colon with ulcer)
Drug ineffective
Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Heart rate increased
Hypertension (high blood pressure)
Leukopenia (less number of white blood cells in blood)

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Emotional distress
Fatigue (feeling of tiredness)
Heart injury
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Pulmonary embolism (blockage of the main artery of the lung)

60+:

Feeling hot
Joint swelling
Local swelling (swelling at the site of some application of substance or injury)
Oedema peripheral (superficial swelling)
Swelling

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 8 people, 26.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 10.00%
Depression: 3 people, 10.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 6.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 6.67%
Asthma: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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