Adderall and Varenicline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) and Varenicline (varenicline). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Adderall and Varenicline. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.

What is Varenicline?

Varenicline has active ingredients of varenicline. It is often used in quit smoking. eHealthMe is studying from 1,066 Varenicline users. Check the latest studies of Varenicline.

On Jul, 09, 2026

13 people who take Adderall and Varenicline together, and have interactions are studied.

Adderall and Varenicline drug interactions.

What are the common drug interactions of Adderall and Varenicline, by gender? *:

female:

Drug ineffective
Upper respiratory tract infection
Meibomian gland dysfunction (dry eyes)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pain
Pain in extremity
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

male:

n/a

What are the common drug interactions of Adderall and Varenicline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Delusion (a false belief or opinion)
Depressed mood
Disturbance in attention
Suicidal ideation

30-39:

Binge eating (pattern of disordered eating which consists of episodes of uncontrollable eating)
Cardiac disorder
Cerebral disorder (brain disease)
Meibomian gland dysfunction (dry eyes)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Road traffic accident
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

40-49:

Hypersensitivity
Injection site swelling
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Pain in extremity
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Secretion discharge
Upper respiratory tract congestion
Upper respiratory tract infection
Drug ineffective

50-59:

n/a

60+:

Asthenia (weakness)
Emotional distress
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Parent-child problem

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 46.15%
Drowsiness: 5 people, 38.46%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 30.77%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 23.08%
Pain: 2 people, 15.38%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 7.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.69%
Headache (pain in head): 1 person, 7.69%
Dyspnea (difficult or laboured breathing): 1 person, 7.69%
Back Pain: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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