Advil cold and sinus and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil cold and sinus (ibuprofen; pseudoephedrine hydrochloride) and Synthroid (levothyroxine sodium). Common drug interactions include diabetic ketoacidosis among females.

The phase IV clinical study analyzes what interactions people have when they take Advil cold and sinus and Synthroid. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Advil cold and sinus?

Advil cold and sinus has active ingredients of ibuprofen; pseudoephedrine hydrochloride. It is often used in sinus headache. eHealthMe is studying from 1,673 Advil cold and sinus users. Check the latest studies of Advil cold and sinus.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,202 Synthroid users. Check the latest studies of Synthroid.

On Aug, 05, 2026

43 people who take Advil cold and sinus and Synthroid together, and have interactions are studied.

Advil cold and sinus and Synthroid drug interactions.

What are the common drug interactions of Advil Cold And Sinus and Synthroid, by gender? *:

female:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Insomnia (sleeplessness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nasopharyngitis (inflammation of the nasopharynx)
Respiratory disorder (respiratory disease)
Swelling face
Duodenal ulcer
Gout (uric acid crystals building up in the body)
Hepatitis (inflammation of the liver)

male:

n/a

What are the common drug interactions of Advil Cold And Sinus and Synthroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

30-39:

Dizziness

40-49:

Drug ineffective
Irritability
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Hypokalaemia (low potassium)
Injection site haemorrhage (bleeding from injection site)
Oral discomfort (pain or irritation in mouth)
Faeces discoloured
Gastric haemorrhage (bleeding stomach)
Acne (skin problems that cause pimples)
Chest pain
Cough
Dyspepsia (indigestion)
Feeling jittery

60+:

Nausea (feeling of having an urge to vomit)
Pain
Insomnia (sleeplessness)
Cough
Nasopharyngitis (inflammation of the nasopharynx)
Respiratory disorder (respiratory disease)
Swelling face
Drug ineffective
Influenza like illness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 27.91%
Thyroid Diseases: 9 people, 20.93%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 20.93%
Malignant Melanoma (skin cancer rises from melancytes): 5 people, 11.63%
Nasopharyngitis (inflammation of the nasopharynx): 4 people, 9.30%
Sinus Disorder (disease of sinus): 3 people, 6.98%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 6.98%
High Blood Pressure: 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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