Advil and Oxycodone hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Advil (ibuprofen) and Oxycodone hydrochloride (oxycodone hydrochloride). Common drug interactions include chronic kidney disease among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Advil and Oxycodone hydrochloride. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Oxycodone hydrochloride?

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 36,817 Oxycodone hydrochloride users. Check the latest studies of Oxycodone hydrochloride.

On Jul, 13, 2026

53 people who take Advil and Oxycodone hydrochloride together, and have interactions are studied.

Advil and Oxycodone hydrochloride drug interactions.

What are the common drug interactions of Advil and Oxycodone Hydrochloride, by gender? *:

female:

Chronic kidney disease
Confusional state
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Depression
Dizziness
Drug abuse
Dry mouth
Dyskinesia (abnormality or impairment of voluntary movement)

male:

Fatigue (feeling of tiredness)
Pain in extremity
Hypoaesthesia (reduced sense of touch or sensation)
Infusion related reaction
Nasopharyngitis (inflammation of the nasopharynx)
Neck injury
Neck pain
Peripheral coldness
Poor quality sleep
Respiratory disorder (respiratory disease)

What are the common drug interactions of Advil and Oxycodone Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthma
Foot fracture
Hypoaesthesia (reduced sense of touch or sensation)
Ligament sprain (ligament stretched)
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Neuroma (tumour of nerve tissue)
Ovarian cyst (fluid filled sac of the ovary)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)

30-39:

Abdominal pain
Cellulitis (infection under the skin)
Cystitis (inflammation of the wall of the bladder)
Fall
Fatigue (feeling of tiredness)
Haematoma (collection of blood outside the blood vessels)
Kidney infection
Pregnancy
Tremor (trembling or shaking movements in one or more parts of your body)
Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation)

40-49:

Fibromyalgia (a long-term condition which causes pain all over the body)
Hot flush (sudden feelings of heat)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypoaesthesia (reduced sense of touch or sensation)
Hysterectomy
Muscle atrophy (a decrease in the mass of the muscle)
Muscle tightness
Neoplasm progression (growth of tumour)
Nephrogenic anaemia (anaemia due to kidney disease)
Pyrexia (fever)

50-59:

Blood pressure decreased
Dizziness
Influenza like illness
Neuropathy peripheral (surface nerve damage)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain in jaw
Pneumonia
Pruritus (severe itching of the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Blood pressure increased
Cervical vertebral fracture
Constipation
Dizziness
Dyspnoea (difficult or laboured respiration)
Gastrointestinal viral infection (virus infection of gastrointestinal tract)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 10 people, 18.87%
Ovarian Cancer (cancer of ovary): 4 people, 7.55%
Breast Cancer Female: 4 people, 7.55%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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