Aerobid and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aerobid (flunisolide) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include haemorrhoids among females and convulsion neonatal among males.

The phase IV clinical study analyzes what interactions people have when they take Aerobid and Flexeril. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Aerobid?

Aerobid has active ingredients of flunisolide. eHealthMe is studying from 1,126 Aerobid users. Check the latest studies of Aerobid.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

27 people who take Aerobid and Flexeril together, and have interactions are studied.

What are the common drug interactions of Aerobid and Flexeril, by gender? *:

female:

Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hepatic lesion
Hilar lymphadenopathy (disease of the lymph nodes due to infection)
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)
Injury
Intervertebral disc protrusion (spinal disc protrusion)
Intervertebral disc space narrowing (spinal disc space narrowing)
Kidney infection
Large intestinal haemorrhage (bleeding in large intestine)

male:

Convulsion neonatal (muscle contraction and relaxation rapidly in neonate)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Agitation (state of anxiety or nervous excitement)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Anxiety
Aphasia (damage to the parts of the brain that control language)
Application site rash
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Breast mass
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)

What are the common drug interactions of Aerobid and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Application site reaction
Depression
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Nervousness
Ovarian cyst (fluid filled sac of the ovary)
Suicidal ideation

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Suicidal ideation
Suicide attempt
Weight increased

40-49:

Convulsion neonatal (muscle contraction and relaxation rapidly in neonate)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Retinal haemorrhage (bleeding from retina)
Sepsis neonatal (a bacterial infection in the blood. it is found in infants during the first month of life)
Talipes
Transverse sinus thrombosis (a blood clot in transverse sinus)
Vitreous haemorrhage (intraocular (inside the eye) bleeding)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

50-59:

Pyrexia (fever)
Abdominal pain
Acute stress disorder
Anaemia (lack of blood)
Anal inflammation
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Arthropathy

60+:

Anxiety
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Arthralgia (joint pain)
Arthropathy
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrioventricular block first degree (heart block first degree)
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)

What are the existing conditions these people have? *

Asthma: 7 people, 25.93%
Depression: 6 people, 22.22%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 14.81%
Pain: 3 people, 11.11%
Pneumonia: 2 people, 7.41%
Obstructive Airways Disorder (a progressive disease that makes it hard to breathe): 2 people, 7.41%
Neuralgia (pain in one or more nerves): 2 people, 7.41%
Mucous Membrane Disorder (disease of mucous membrane): 2 people, 7.41%
Liver Disorder (liver diseases): 2 people, 7.41%
Itching: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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