Afinitor and Boniva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Afinitor (everolimus) and Boniva (ibandronate sodium). Common drug interactions include pruritus among females and femur fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Afinitor and Boniva. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Afinitor?

Afinitor has active ingredients of everolimus. It is often used in breast cancer metastatic. eHealthMe is studying from 41,680 Afinitor users. Check the latest studies of Afinitor.

What is Boniva?

Boniva has active ingredients of ibandronate sodium. It is often used in osteoporosis. eHealthMe is studying from 27,340 Boniva users. Check the latest studies of Boniva.

On Jul, 31, 2026

16 people who take Afinitor and Boniva together, and have interactions are studied.

What are the common drug interactions of Afinitor and Boniva, by gender? *:

female:

Pruritus (severe itching of the skin)
Recurrent cancer (repeated cancer)
Red blood cell count decreased
Renal cancer (cancer of kidney)
Temperature intolerance (inability to go in temperature)
Tinnitus (a ringing in the ears)
Type 1 diabetes mellitus
Vaginal inflammation
Vision blurred
Weight decreased

male:

Femur fracture
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Sinusitis (inflammation of sinus)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tooth abscess (pus formation in tooth)
Upper respiratory tract infection
Weight decreased
Pneumonia
Neoplasm malignant (cancer tumour)

What are the common drug interactions of Afinitor and Boniva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood pressure decreased
Dehydration (dryness resulting from the removal of water)
Dizziness
Loss of consciousness
Sinusitis (inflammation of sinus)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tooth abscess (pus formation in tooth)
Tooth infection
Upper respiratory tract infection
Weight decreased

30-39:

Psoriasis (immune-mediated disease that affects the skin)
Somnolence (a state of near-sleep, a strong desire for sleep)
Urinary tract infection
Abasia (inability to walk)
Blood cholesterol increased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)

40-49:

Abdominal discomfort
Arthralgia (joint pain)
Back pain
Bone pain
Diastolic dysfunction
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic lesion
Herpes simplex (herpes simplex is a common viral infection)

50-59:

Anxiety
Emotional distress
Femur fracture
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Stomatitis (inflammation of mucous membrane of mouth)
Nausea (feeling of having an urge to vomit)
Neoplasm malignant (cancer tumour)
Asthenia (weakness)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

60+:

Pneumonia
Arthralgia (joint pain)
Fall
Femur fracture
Hydronephrosis (water inside the kidney)
Hypermetropia (abnormal condition in which vision for distant objects is better than for near objects)
Hypersensitivity
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Nephrolithiasis (calculi in the kidneys)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the existing conditions these people have? *

Osteopenia (a condition where bone mineral density is lower than normal): 5 people, 31.25%
Renal Cell Carcinoma (a kidney cancer): 3 people, 18.75%
Angiomyolipoma (most common benign tumour of the kidney): 3 people, 18.75%
Breast Cancer Female: 2 people, 12.50%
Pancreatic Carcinoma (pancreatic cancer): 1 person, 6.25%
Malignant Urinary Tract Neoplasm (cancer tumour of urinary tract organs): 1 person, 6.25%
High Blood Pressure: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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