Afinitor and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Afinitor (everolimus) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include cardiomyopathy among females and malaise among males.

The phase IV clinical study analyzes what interactions people have when they take Afinitor and Hydramine. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Afinitor?

Afinitor has active ingredients of everolimus. It is often used in breast cancer metastatic. eHealthMe is studying from 41,680 Afinitor users. Check the latest studies of Afinitor.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 31, 2026

54 people who take Afinitor and Hydramine together, and have interactions are studied.

Afinitor and Hydramine drug interactions.

What are the common drug interactions of Afinitor and Hydramine, by gender? *:

female:

Cardiomyopathy (weakening of the heart muscle)
Cellulitis (infection under the skin)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Decreased appetite
Depression
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dermatophytosis (inflammation of the skin and underlying muscle tissue)
Dry mouth
Dysphagia (a condition in which swallowing is difficult or painful)
Erythema (redness of the skin)

male:

Malaise (a feeling of general discomfort or uneasiness)
Postoperative wound complication
Dizziness
Dyspnoea exertional (breathlessness or shortness of breath)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Thrombocytopenia (decrease of platelets in blood)
Back pain
Oedema peripheral (superficial swelling)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the common drug interactions of Afinitor and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Hypertriglyceridaemia (excess of triglycerides in the blood)
Optic nerve disorder (disease of optic nerve)
Blastomycosis (fungal infection caused by fungus blastomyces dermatitidis)
Fatigue (feeling of tiredness)
Pyrexia (fever)
Device related infection
Epistaxis (bleed from the nose)
Malaise (a feeling of general discomfort or uneasiness)

20-29:

Kidney infection

30-39:

Decreased appetite
Dehydration (dryness resulting from the removal of water)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Nausea (feeling of having an urge to vomit)
Vomiting

40-49:

Chest pain
Cough
Death
Dyspnoea (difficult or laboured respiration)
Interstitial lung disease
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pyrexia (fever)

50-59:

Thrombocytopenia (decrease of platelets in blood)
Disease progression
Pain in extremity
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Haematochezia (passage of stools containing blood)
Hypersensitivity
Hypotension (abnormally low blood pressure)
Influenza like illness
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

60+:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Hyperglycaemia (high blood sugar)
Neoplasm progression (growth of tumour)
Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
Peripheral sensory neuropathy (damage to one or more of your peripheral nerves)
Rash
Vomiting
Alopecia (absence of hair from areas of the body)
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Breast Cancer: 14 people, 25.93%
Renal Cell Carcinoma (a kidney cancer): 6 people, 11.11%
Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues): 5 people, 9.26%
Rashes (redness): 4 people, 7.41%
Pneumonia: 4 people, 7.41%
Paronychia (infection in the tissues adjacent to a nail on a finger or toe): 4 people, 7.41%
Nausea (feeling of having an urge to vomit): 4 people, 7.41%
Infection: 4 people, 7.41%
High Blood Pressure: 4 people, 7.41%
Lung Neoplasm Malignant (cancer tumour of lung): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Afinitor and Hydramine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously