Aldactazide and Gabapentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactazide (hydrochlorothiazide; spironolactone) and Gabapentin (gabapentin). Common drug interactions include weight decreased among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactazide and Gabapentin. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactazide?

Aldactazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 1,597 Aldactazide users. Check the latest studies of Aldactazide.

What is Gabapentin?

Gabapentin has active ingredients of gabapentin. It is often used in peripheral neuropathy. eHealthMe is studying from 322,990 Gabapentin users. Check the latest studies of Gabapentin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

53 people who take Aldactazide and Gabapentin together, and have interactions are studied.

Aldactazide and Gabapentin drug interactions.

What are the common drug interactions of Aldactazide and Gabapentin, by gender? *:

female:

Weight decreased
Fall
Malaise (a feeling of general discomfort or uneasiness)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephrolithiasis (calculi in the kidneys)
Renal failure (kidney dysfunction)
Tooth disorder (tooth disease)
Vomiting
Acidosis (build-up of carbon dioxide in the blood)
Agitation (state of anxiety or nervous excitement)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperkalaemia (damage to or disease of the kidney)
Pneumonia
Renal injury (kidney injury)
Restless legs syndrome (a powerful urge to move your legs)
Screaming (a long loud piercing cry)
Tremor (trembling or shaking movements in one or more parts of your body)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the common drug interactions of Aldactazide and Gabapentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Electrolyte imbalance
Weight decreased
Cardiac failure
Heart transplant
Protein-losing gastroenteropathy (gastrointestinal tract that results in a net loss of protein from the body)

20-29:

n/a

30-39:

Agitation (state of anxiety or nervous excitement)
Attention deficit/hyperactivity disorder
Bipolar disorder (mood disorder)
Cervical cyst (mucus-filled cyst on the surface of the cervix)
Chest discomfort
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Exostosis (formation of new bone on the surface of a bone)
Gastroenteritis (inflammation of stomach and intestine)
Gingivitis (inflammation of gums)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

40-49:

Nephrolithiasis (calculi in the kidneys)

50-59:

Dyslipidaemia (abnormal amount of lipids)
Gout (uric acid crystals building up in the body)
Hypokalaemia (low potassium)
Intermittent claudication
Renal impairment (severely reduced kidney function)
Staphylococcal infection (an infection with staphylococcus bacteria)
Anxiety
Arthropathy
Depression
Renal tubular necrosis (death of kidney tubules)

60+:

Dyspnoea (difficult or laboured respiration)
Hypoacusis (loss of hearing)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Renal failure (kidney dysfunction)
Vomiting
Arthralgia (joint pain)
Fall
Gout (uric acid crystals building up in the body)
Headache (pain in head)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

What are the existing conditions these people have? *

Pain: 15 people, 28.30%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 26.42%
High Blood Cholesterol: 9 people, 16.98%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 15.09%
Headache (pain in head): 6 people, 11.32%
Back Pain: 5 people, 9.43%
Diabetes: 5 people, 9.43%
Gastric Ulcer (stomach ulcer): 5 people, 9.43%
Neuralgia (pain in one or more nerves): 5 people, 9.43%
Gout (uric acid crystals building up in the body): 5 people, 9.43%

* Approximation only. Some reports may have incomplete information.

Do you take Aldactazide and Gabapentin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously