Aldactazide and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactazide (hydrochlorothiazide; spironolactone) and Zoloft (sertraline hydrochloride). Common drug interactions include eye discharge among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactazide and Zoloft. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactazide?

Aldactazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 1,597 Aldactazide users. Check the latest studies of Aldactazide.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 19, 2026

61 people who take Aldactazide and Zoloft together, and have interactions are studied.

Aldactazide and Zoloft drug interactions.

What are the common drug interactions of Aldactazide and Zoloft, by gender? *:

female:

Eye discharge
Eye infection viral
Eye irritation
Eye pruritus (eye itching)
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Haematoma (collection of blood outside the blood vessels)
Haemoglobin decreased
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Hypercholesterolaemia (high levels of cholesterol in the blood)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Abdominal discomfort
Muscle spasms (muscle contraction)
Pain
Pain in extremity
Sinusitis (inflammation of sinus)
Acute hepatic failure
Acute respiratory failure
Anger

What are the common drug interactions of Aldactazide and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nephrolithiasis (calculi in the kidneys)

50-59:

Hyperglycaemia (high blood sugar)
Hypokalaemia (low potassium)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pain
Renal failure (kidney dysfunction)
Septic shock (shock due to blood infection)
Vertigo
Weight increased
Acute hepatic failure

60+:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Confusional state
Nausea (feeling of having an urge to vomit)
Renal injury (kidney injury)
Vomiting
Blood creatine phosphokinase increased
Blood thyroid stimulating hormone decreased
Cardiac failure congestive
Decreased appetite
Drug ineffective

What are the existing conditions these people have? *

Pain: 8 people, 13.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.84%
High Blood Cholesterol: 5 people, 8.20%
Renal Impairment (severely reduced kidney function): 4 people, 6.56%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 6.56%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 6.56%
Back Pain: 4 people, 6.56%

* Approximation only. Some reports may have incomplete information.

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