Aldactone and Azactam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Azactam (aztreonam). Common drug interactions include atrioventricular block complete among females and agranulocytosis among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Azactam. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Azactam?

Azactam has active ingredients of aztreonam. eHealthMe is studying from 1,044 Azactam users. Check the latest studies of Azactam.

On Jul, 14, 2026

18 people who take Aldactone and Azactam together, and have interactions are studied.

Aldactone and Azactam drug interactions.

What are the common drug interactions of Aldactone and Azactam, by gender? *:

female:

Atrioventricular block complete (heart block complete)
Injury
Pain
Renal failure (kidney dysfunction)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Cardiac failure
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Psychiatric symptom
Alanine aminotransferase increased

male:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Pyrexia (fever)
Weight increased
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Bacterial sepsis
C-reactive protein increased
Cardiac disorder
Cardiac ventricular thrombosis (blood clot in ventricle)
Circulatory collapse
Drug ineffective

What are the common drug interactions of Aldactone and Azactam, by age (0-1 to 60+)? *:

0-1:

Bacterial sepsis
C-reactive protein increased
Cardiac disorder
Cardiac ventricular thrombosis (blood clot in ventricle)
Circulatory collapse
Drug ineffective
Sepsis (a severe blood infection that can lead to organ failure and death)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Weight increased

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardiac failure

40-49:

n/a

50-59:

Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood lactate dehydrogenase increased
Hepatic function abnormal
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Sputum culture positive

60+:

Atrioventricular block complete (heart block complete)
Injury
Chest pain
Coagulopathy (blood's ability to clot is impaired)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Kidney infection
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nodal rhythm (40-50 beats per minute)
Pruritus (severe itching of the skin)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)

What are the existing conditions these people have? *

Urinary Tract Infection Pseudomonal: 2 people, 11.11%
Bleeding Disorders: 2 people, 11.11%
Immunodeficiency Disorders: 2 people, 11.11%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 11.11%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 1 person, 5.56%
Pneumonia: 1 person, 5.56%
Osteomyelitis Chronic (long lasting infection of bone marrow): 1 person, 5.56%
Lung Disorder (lung disease): 1 person, 5.56%
Infection: 1 person, 5.56%
Stress Gastritis (swelling (inflammation) and weakening of the stomach lining that occurs during a serious illness): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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