Aldactone and Codeine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Codeine sulfate (codeine sulfate). Common drug interactions include confusional state among females and hepatic neoplasm malignant among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Codeine sulfate. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Codeine sulfate?

Codeine sulfate has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 4,510 Codeine sulfate users. Check the latest studies of Codeine sulfate.

On Jul, 17, 2026

25 people who take Aldactone and Codeine sulfate together, and have interactions are studied.

Aldactone and Codeine sulfate drug interactions.

What are the common drug interactions of Aldactone and Codeine Sulfate, by gender? *:

female:

Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Impaired gastric emptying
Increased bronchial secretion
Malaise (a feeling of general discomfort or uneasiness)
Stress
Abasia (inability to walk)
Abdominal pain
Acute myocardial infarction (acute heart attack)

male:

Hepatic neoplasm malignant (liver cancer)
Cerebral haemorrhage (bleeding within the brain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood amylase increased
Blood glucose increased
Blood potassium decreased
Cardiomyopathy (weakening of the heart muscle)
Cholangitis (infection of the bile duct)
Dehydration (dryness resulting from the removal of water)
Disseminated intravascular coagulation (systemic activation of blood coagulation)

What are the common drug interactions of Aldactone and Codeine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Myalgia (muscle pain)
Pruritus (severe itching of the skin)
Skin burning sensation
Abdominal distension
Abdominal pain
Anaemia (lack of blood)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood amylase increased
Blood creatinine increased

50-59:

Cerebral haemorrhage (bleeding within the brain)
Hepatic neoplasm malignant (liver cancer)
Respiratory failure (inadequate gas exchange by the respiratory system)
Cholangitis (infection of the bile duct)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypertransaminasaemia

60+:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Cough
Platelet count decreased
Arthralgia (joint pain)
Decreased appetite
Nausea (feeling of having an urge to vomit)
Pneumonia
Anaemia (lack of blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood urea increased

What are the existing conditions these people have? *

Hepatic Neoplasm Malignant (liver cancer): 5 people, 20.00%
High Blood Pressure: 4 people, 16.00%
Varices Oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach): 3 people, 12.00%
Pancreatic Carcinoma Non-Resectable (pancreatic cancer- non-resectable): 3 people, 12.00%
Oedema (fluid collection in tissue): 3 people, 12.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 12.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 12.00%
Diarrhea: 3 people, 12.00%
Diabetes: 3 people, 12.00%
Cancer Pain: 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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