Aldactone and Nitrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aldactone (spironolactone) and Nitrol (nitroglycerin). Common drug interactions include stress among females and atrial flutter among males.

The phase IV clinical study analyzes what interactions people have when they take Aldactone and Nitrol. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Nitrol?

Nitrol has active ingredients of nitroglycerin. eHealthMe is studying from 3,069 Nitrol users. Check the latest studies of Nitrol.

On Jul, 14, 2026

58 people who take Aldactone and Nitrol together, and have interactions are studied.

What are the common drug interactions of Aldactone and Nitrol, by gender? *:

female:

Stress
Heart rate irregular
Anaemia (lack of blood)
Cardiac arrest
Cardiomyopathy (weakening of the heart muscle)
Cough
Dyspnoea exertional (breathlessness or shortness of breath)
Oedema peripheral (superficial swelling)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Vomiting

male:

Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Escherichia test positive
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Pneumonia
Respiratory depression (respiration has a rate below 12 breaths)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Abdominal distension
Syncope (loss of consciousness with an inability to maintain postural tone)
Angina pectoris (chest pain due to ischemia of the heart muscle)

What are the common drug interactions of Aldactone and Nitrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiomegaly (increased size of heart than normal)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Oedema (fluid collection in tissue)
Pleural effusion (water on the lungs)
Stress
Back pain
Cardiomyopathy (weakening of the heart muscle)
Dyspnoea exertional (breathlessness or shortness of breath)
Injury

50-59:

Pain
Abdominal distension
Aortic valve incompetence
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coronary artery bypass

60+:

Pain
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Cytomegalovirus infection
Decreased appetite
Delirium (wild excitement)
Escherichia test positive
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperkalaemia (damage to or disease of the kidney)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 12 people, 20.69%
High Blood Pressure: 10 people, 17.24%
Stable Angina (a constant chest pain): 8 people, 13.79%
Cardiac Failure: 7 people, 12.07%
High Blood Cholesterol: 5 people, 8.62%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 8.62%
Pain: 5 people, 8.62%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 4 people, 6.90%
Chest Pain: 4 people, 6.90%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 4 people, 6.90%

* Approximation only. Some reports may have incomplete information.

Do you take Aldactone and Nitrol?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously