Aleve pm and Gabapentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve pm (diphenhydramine hydrochloride; naproxen sodium) and Gabapentin (gabapentin). Common drug interactions include paraesthesia among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve pm and Gabapentin. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve pm?

Aleve pm has active ingredients of diphenhydramine hydrochloride; naproxen sodium. eHealthMe is studying from 2,094 Aleve pm users. Check the latest studies of Aleve pm.

What is Gabapentin?

Gabapentin has active ingredients of gabapentin. It is often used in neuralgia. eHealthMe is studying from 322,983 Gabapentin users. Check the latest studies of Gabapentin.

On Jul, 16, 2026

40 people who take Aleve pm and Gabapentin together, and have interactions are studied.

Aleve pm and Gabapentin drug interactions.

What are the common drug interactions of Aleve Pm and Gabapentin, by gender? *:

female:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Restlessness (not able to rest)
Salivary hypersecretion (excess saliva secretion)
Vulvovaginal burning sensation
Vulvovaginal pruritus (vulvovaginal severe itching)
Wound infection staphylococcal
Fatigue (feeling of tiredness)
Headache (pain in head)
Constipation

male:

Weight decreased
Fall
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gait disturbance
Haematuria (presence of blood in urine)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Increased upper airway secretion
Limb discomfort (discomfort in leg)

What are the common drug interactions of Aleve Pm and Gabapentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Chills (felling of cold)
Hot flush (sudden feelings of heat)
Nausea (feeling of having an urge to vomit)

40-49:

Wound infection staphylococcal
Dyspnoea (difficult or laboured respiration)
Somnolence (a state of near-sleep, a strong desire for sleep)
Acute respiratory failure
Anaemia (lack of blood)
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Blood creatine increased
Cancer pain

50-59:

Headache (pain in head)
Dysgeusia (disorder of the sense of taste)
Nausea (feeling of having an urge to vomit)
Salivary hypersecretion (excess saliva secretion)

60+:

Constipation
Fluid overload (too much fluid in the blood)
Bladder neoplasm (bladder tumour)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Concussion (short loss of normal brain function in response to a head injury)
Diarrhoea
Dizziness
Dysgeusia (disorder of the sense of taste)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Pain: 15 people, 37.50%
Insomnia (sleeplessness): 9 people, 22.50%
Sleep Disorder: 7 people, 17.50%
Constipation: 6 people, 15.00%
Back Pain: 5 people, 12.50%
Stress And Anxiety: 4 people, 10.00%
High Blood Pressure: 4 people, 10.00%
Multiple Myeloma (cancer of the plasma cells): 4 people, 10.00%
Nausea (feeling of having an urge to vomit): 4 people, 10.00%
Nausea And Vomiting: 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Aleve pm and Gabapentin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously