Aleve and Hydroxyzine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Aleve (naproxen sodium) and Hydroxyzine hydrochloride (hydroxyzine hydrochloride). Common drug interactions include addison's disease among females and gallbladder disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Aleve and Hydroxyzine hydrochloride. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

What is Hydroxyzine hydrochloride?

Hydroxyzine hydrochloride has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 10,486 Hydroxyzine hydrochloride users. Check the latest studies of Hydroxyzine hydrochloride.

On Jul, 16, 2026

63 people who take Aleve and Hydroxyzine hydrochloride together, and have interactions are studied.

Aleve and Hydroxyzine hydrochloride drug interactions.

What are the common drug interactions of Aleve and Hydroxyzine Hydrochloride, by gender? *:

female:

Addison's disease (addison's disease, a hormonal disorder disease)
Adnexa uteri mass (ovarian cysts)
Adverse drug reaction
Amyotrophic lateral sclerosis (nervous system disease that attacks nerve cells called neurons in your brain and spinal cord)
Fatigue (feeling of tiredness)
Sinusitis (inflammation of sinus)
Dizziness
Hypoaesthesia (reduced sense of touch or sensation)
Gait disturbance
Hepatic enzyme increased

male:

Gallbladder disorder
Abdominal pain
Fatigue (feeling of tiredness)
Hospitalisation
Injection site pain
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Osteoporosis (bones weak and more likely to break)
Panic attack
Rash macular (small, flat red spots)

What are the common drug interactions of Aleve and Hydroxyzine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Back pain
Influenza
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Rhinorrhoea (watery mucus discharge from the nose)
Nasopharyngitis (inflammation of the nasopharynx)

20-29:

Gallbladder disorder

30-39:

Head discomfort
Abdominal pain
Dizziness
Ear infection
Fall
Fatigue (feeling of tiredness)
Gait disturbance
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hepatic enzyme increased
Hepatitis b

40-49:

Ankle fracture
Balance disorder
Fatigue (feeling of tiredness)
Hospitalisation
Injection site pain
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Neuropathy peripheral (surface nerve damage)
Panic attack
Road traffic accident

50-59:

Mood disorder due to a general medical condition
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myalgia (muscle pain)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nausea (feeling of having an urge to vomit)
Neck pain
Neoplasm (tumour)

60+:

Fatigue (feeling of tiredness)
Asthma
Abdominal pain
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood pressure decreased
Blood pressure increased
Cholecystitis (infection of gallbladder)
Chronic kidney disease
Constipation
Diarrhoea

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 23.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 20.63%
Immunodeficiency Common Variable: 10 people, 15.87%
High Blood Pressure: 6 people, 9.52%
Rickets (softening of bones): 5 people, 7.94%
Type 2 Diabetes: 4 people, 6.35%
Secondary Immunodeficiency (lack of immunity due to some disease): 4 people, 6.35%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 6.35%
Erection Problems: 4 people, 6.35%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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