Alkeran and Synthroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alkeran (melphalan) and Synthroid (levothyroxine sodium). Common drug interactions include bone disorder among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Alkeran and Synthroid. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Alkeran?

Alkeran has active ingredients of melphalan. eHealthMe is studying from 5,429 Alkeran users. Check the latest studies of Alkeran.

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 249,198 Synthroid users. Check the latest studies of Synthroid.

On Jul, 12, 2026

32 people who take Alkeran and Synthroid together, and have interactions are studied.

Alkeran and Synthroid drug interactions.

What are the common drug interactions of Alkeran and Synthroid, by gender? *:

female:

Bone disorder
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Diarrhoea
Actinomycosis (infection that causes sores, or abscesses)
Asthenia (weakness)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bone erosion
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Colonic polyp (extra part of colon tissue grow in intestine)

male:

Renal failure (kidney dysfunction)
Asthenia (weakness)
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Back pain
Bone marrow failure
Cataract (clouding of the lens inside the eye)
Cellulitis (infection under the skin)
Cystitis (inflammation of the wall of the bladder)
Deformity (disfigurement)

What are the common drug interactions of Alkeran and Synthroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Actinic keratosis (skin disease due to sun exposure)
Actinomycosis (infection that causes sores, or abscesses)
Actinomycotic skin infection (infectious and inflammatory diseases affect the skin and the oral mucosa)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic calcification (aortic calcification sign of heart valve disease)
Arrhythmia (irregular heartbeat)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)

50-59:

Pneumonia
Renal failure chronic (long lasting kidney dysfunction)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Influenza
Muscle spasms (muscle contraction)

60+:

Asthenia (weakness)
Pain in jaw
Osteonecrosis of jaw (death of bone of jaw)
Renal failure (kidney dysfunction)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Actinomycosis (infection that causes sores, or abscesses)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bone erosion
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 18 people, 56.25%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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