Allegra and Actifed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Allegra (fexofenadine hydrochloride) and Actifed (pseudoephedrine hydrochloride; triprolidine hydrochloride). Common drug interactions include muscle spasms among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Allegra and Actifed. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Allegra?

Allegra has active ingredients of fexofenadine hydrochloride. It is often used in allergies. eHealthMe is studying from 75,498 Allegra users. Check the latest studies of Allegra.

What is Actifed?

Actifed has active ingredients of pseudoephedrine hydrochloride; triprolidine hydrochloride. It is often used in allergies. eHealthMe is studying from 1,091 Actifed users. Check the latest studies of Actifed.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

15 people who take Allegra and Actifed together, and have interactions are studied.

What are the common drug interactions of Allegra and Actifed, by gender? *:

female:

Muscle spasms (muscle contraction)
Adverse drug reaction
Anosmia (partial or complete loss of the sense of smell)
Back pain
Blood triglycerides increased
Constipation
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Laryngitis (inflammation of the larynx)

male:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Pruritus (severe itching of the skin)
Peripheral arterial occlusive disease (reproducible ischemic muscle pain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Blood cholesterol increased
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Headache (pain in head)
Hypophysitis (inflammation of the pituitary gland)

What are the common drug interactions of Allegra and Actifed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Pruritus (severe itching of the skin)

20-29:

Anosmia (partial or complete loss of the sense of smell)
Taste loss

30-39:

Back pain
Pneumonia

40-49:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Laryngitis (inflammation of the larynx)
Sleep disorder
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Blood cholesterol increased

60+:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Muscle spasms (muscle contraction)
Photophobia (extreme sensitivity to light)
Peripheral arterial occlusive disease (reproducible ischemic muscle pain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Adverse drug reaction
Constipation

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 4 people, 26.67%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 20.00%
Asthma: 2 people, 13.33%
Seasonal Allergy (allergic condition due to certain season): 1 person, 6.67%
Malignant Melanoma (skin cancer rises from melancytes): 1 person, 6.67%
Hypersensitivity: 1 person, 6.67%
High Blood Cholesterol: 1 person, 6.67%
Headache (pain in head): 1 person, 6.67%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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