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Alphagan and Cevimeline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alphagan (brimonidine tartrate) and Cevimeline (cevimeline hydrochloride). Common drug interactions include pruritus among females.

The phase IV clinical study analyzes what interactions people have when they take Alphagan and Cevimeline. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.

What is Cevimeline?

Cevimeline has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 1,480 Cevimeline users. Check the latest studies of Cevimeline.

On Jul, 27, 2026

11 people who take Alphagan and Cevimeline together, and have interactions are studied.

Alphagan and Cevimeline drug interactions.

What are the common drug interactions of Alphagan and Cevimeline, by gender? *:

female:

  1. Pruritus (severe itching of the skin)
  2. Death
  3. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  4. Haematemesis (vomiting of blood)
  5. Herpes zoster
  6. Hypotension (abnormally low blood pressure)
  7. Influenza
  8. Multiple allergies (allergy to multiple agents)
  9. Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
  10. Neuralgia (pain in one or more nerves)

male:

n/a

What are the common drug interactions of Alphagan and Cevimeline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Death
  2. Pruritus (severe itching of the skin)
  3. Neuralgia (pain in one or more nerves)
  4. Rash
  5. Anaemia (lack of blood)
  6. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  7. Blood pressure increased
  8. Burning sensation
  9. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  10. Haematemesis (vomiting of blood)

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 8 people, 72.73%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
  3. Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 9.09%
  4. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Alphagan and Cevimeline?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Alphagan and Cevimeline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Alphagan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Cevimeline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Alphagan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cevimeline and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on brimonidine tartrate and cevimeline hydrochloride (the active ingredients of Alphagan and Cevimeline, respectively), and Alphagan and Cevimeline (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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