Alphagan and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alphagan (brimonidine tartrate) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include dyspnoea among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Alphagan and Hydroxyzine. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 15, 2026

72 people who take Alphagan and Hydroxyzine together, and have interactions are studied.

Alphagan and Hydroxyzine drug interactions.

What are the common drug interactions of Alphagan and Hydroxyzine, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Fall
Fatigue (feeling of tiredness)
Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Malaise (a feeling of general discomfort or uneasiness)
Blindness unilateral
Blood pressure increased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

male:

Pain
Dizziness
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Chondropathy (disease of the cartilage)
Emotional distress
Essential hypertension (primary hypertension)

What are the common drug interactions of Alphagan and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dyspnoea (difficult or laboured respiration)
Respiratory tract congestion (blockage on respiratory system)
Abdominal pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cerebrovascular disorder (disease of brain)
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrointestinal pain

50-59:

Joint swelling
Oxygen saturation decreased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Bone loss
Chondropathy (disease of the cartilage)
Emotional distress
Gait disturbance
Muscle atrophy (a decrease in the mass of the muscle)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

60+:

Chronic kidney disease
Fall
Arrhythmia (irregular heartbeat)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Chest pain
Disease recurrence
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Gastric disorder (disease of stomach)

What are the existing conditions these people have? *

High Blood Pressure: 11 people, 15.28%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 13.89%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 12.50%
Cardiac Disorder: 9 people, 12.50%
Multiple Myeloma (cancer of the plasma cells): 7 people, 9.72%
Hiv Infection: 7 people, 9.72%
Pain: 6 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 8.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 6.94%
Itching: 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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