Alprazolam and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alprazolam (alprazolam) and Rapamune (sirolimus). Common drug interactions include hypertension among females and neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Alprazolam and Rapamune. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Alprazolam?

Alprazolam has active ingredients of alprazolam. It is often used in stress and anxiety. eHealthMe is studying from 134,864 Alprazolam users. Check the latest studies of Alprazolam.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.



On Jul, 05, 2026

44 people who take Alprazolam and Rapamune together, and have interactions are studied.

Alprazolam and Rapamune drug interactions.

What are the common drug interactions of Alprazolam and Rapamune, by gender? *:

female:

  1. Hypertension (high blood pressure)
  2. Abdominal pain
  3. Adenoma benign (non-cancerous tumour -secreting)
  4. Aphasia (damage to the parts of the brain that control language)
  5. Blood cholesterol increased
  6. Blood disorder
  7. Cold sweat
  8. Cytomegalovirus infection
  9. Diarrhoea
  10. Dizziness

male:

  1. Neutropenia (an abnormally low number of neutrophils)
  2. Lymphoma (cancer that begins in immune system cells)
  3. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  4. Hypotension (abnormally low blood pressure)
  5. Loss of consciousness
  6. Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
  7. Pneumonia
  8. Renal failure chronic (long lasting kidney dysfunction)
  9. Sepsis (a severe blood infection that can lead to organ failure and death)
  10. Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

What are the common drug interactions of Alprazolam and Rapamune, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Abdominal infection
  2. Abdominal pain upper
  3. Acidosis (build-up of carbon dioxide in the blood)
  4. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  5. Asthenia (weakness)
  6. Back pain
  7. Blood cholesterol increased
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  9. Bronchopleural fistula
  10. Cardiac failure congestive

30-39:

  1. Anaemia (lack of blood)
  2. Complications of transplanted kidney
  3. Confusional state
  4. Dyskinesia (abnormality or impairment of voluntary movement)
  5. Dyspnoea (difficult or laboured respiration)
  6. Eye disorder
  7. Hemiplegia (paralysis of one side of the body)
  8. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  9. Procedural pain
  10. Pulmonary congestion (congestion in the lungs)

40-49:

  1. Abdominal pain
  2. Adenoma benign (non-cancerous tumour -secreting)
  3. Diarrhoea
  4. Hypertriglyceridaemia (excess of triglycerides in the blood)
  5. Pancreatic insufficiency
  6. Pancreatic pseudocyst (collection of tissue and fluids that forms on pancreas)
  7. Pancreatitis chronic (chronic inflammation of pancreas)
  8. Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
  9. Blood creatinine increased
  10. Chronic kidney disease

50-59:

  1. Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
  2. Pyrexia (fever)
  3. Renal tubular disorder (disease of kidney tubules)
  4. Thrombotic thrombocytopenic purpura (a rare blood disorder characterized by clotting in small blood vessels of the body)
  5. Urinary fistula
  6. Abdominal distension
  7. Abdominal pain upper
  8. Atelectasis (partial or complete collapse of the lung)
  9. Bile duct cancer
  10. Bile duct cancer recurrent

60+:

  1. Neutropenia (an abnormally low number of neutrophils)
  2. Lymphoma (cancer that begins in immune system cells)
  3. Vomiting
  4. Anaemia (lack of blood)
  5. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  6. Dementia (madness)
  7. General physical health deterioration (weak health status)
  8. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  9. Hypotension (abnormally low blood pressure)
  10. Loss of consciousness

What are the existing conditions these people have? *

  1. Gout (uric acid crystals building up in the body): 6 people, 13.64%
  2. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 11.36%
  3. Immunodeficiency Disorders: 4 people, 9.09%
  4. High Blood Pressure: 4 people, 9.09%
  5. Sleep Disorder: 3 people, 6.82%
  6. Constipation: 3 people, 6.82%
  7. Chronic Kidney Disease: 3 people, 6.82%
  8. Cardiac Disorder: 3 people, 6.82%
  9. Blood Pressure Abnormal: 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Alprazolam and Rapamune:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Alprazolam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Rapamune:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Alprazolam and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rapamune and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on alprazolam and sirolimus (the active ingredients of Alprazolam and Rapamune, respectively), and Alprazolam and Rapamune (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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