Alprostadil and Isosorbide mononitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alprostadil (alprostadil) and Isosorbide mononitrate (isosorbide mononitrate). Common drug interactions include lung infection among females and lymphocyte count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Alprostadil and Isosorbide mononitrate. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Alprostadil?

Alprostadil has active ingredients of alprostadil. It is often used in erection problems. eHealthMe is studying from 2,653 Alprostadil users. Check the latest studies of Alprostadil.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

69 people who take Alprostadil and Isosorbide mononitrate together, and have interactions are studied.

Alprostadil and Isosorbide mononitrate drug interactions.

What are the common drug interactions of Alprostadil and Isosorbide Mononitrate, by gender? *:

female:

Lung infection
Anaemia (lack of blood)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Cardiac arrest
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Red blood cells urine positive
Upper respiratory tract infection
White blood cell count increased
Blood urine present

male:

Lymphocyte count decreased
Blood urea increased
Alanine aminotransferase increased
Glomerular filtration rate decreased
Bk virus infection
Diarrhoea
Abdominal distension
Urinary tract infection
Blood albumin decreased
Protein urine present

What are the common drug interactions of Alprostadil and Isosorbide Mononitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Complications of transplanted kidney
Urine output decreased

30-39:

Haemoglobin decreased
Blood urea increased
Lymphocyte count decreased
Platelet count decreased
Blood albumin decreased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Abdominal distension
Alanine aminotransferase increased
Anaemia (lack of blood)
Bk virus infection

40-49:

Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Lymphocyte count decreased
Anaemia (lack of blood)
Platelet count decreased
Glomerular filtration rate decreased
Bilirubin conjugated increased
Incision site pain
White blood cell count increased
Hyperkalaemia (damage to or disease of the kidney)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Lymphocyte count decreased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Blood urea increased
White blood cell count increased
Pyrexia (fever)
Blood glucose increased
Cough
Alanine aminotransferase increased
Bk virus infection
Diarrhoea

60+:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Aortic bruit (unusual sound that blood makes when it rushes past an obstruction in aortic artery)
Asthenia (weakness)
Back pain
Blood creatine phosphokinase increased
Blood creatine phosphokinase mb increased
Blood creatinine increased
Blood potassium increased

What are the existing conditions these people have? *

High Blood Pressure: 47 people, 68.12%
Diarrhea: 25 people, 36.23%
Urination - Excessive Volume: 23 people, 33.33%
Productive Cough: 21 people, 30.43%
Inflammation: 20 people, 28.99%
Anaemia (lack of blood): 18 people, 26.09%
Blood Glucose Increased: 16 people, 23.19%
Constipation: 16 people, 23.19%
Infection: 13 people, 18.84%
Nausea And Vomiting: 10 people, 14.49%

* Approximation only. Some reports may have incomplete information.

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