Alprostadil and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Alprostadil (alprostadil) and Spironolactone (spironolactone). Common drug interactions include nephrogenic anaemia among females and lymphocyte count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Alprostadil and Spironolactone. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Alprostadil?

Alprostadil has active ingredients of alprostadil. It is often used in erection problems. eHealthMe is studying from 2,653 Alprostadil users. Check the latest studies of Alprostadil.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

On Jul, 05, 2026

85 people who take Alprostadil and Spironolactone together, and have interactions are studied.

Alprostadil and Spironolactone drug interactions.

What are the common drug interactions of Alprostadil and Spironolactone, by gender? *:

female:

Nephrogenic anaemia (anaemia due to kidney disease)
Anaemia (lack of blood)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Blood glucose increased
Extremity necrosis (death of body tissue of arms and legs)
Gastroenteritis (inflammation of stomach and intestine)

male:

Lymphocyte count decreased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Pain in extremity
Upper respiratory tract infection
Urinary tract infection
White blood cell count increased
Cardiac failure
Anaemia (lack of blood)
Bk virus infection
Blood glucose increased

What are the common drug interactions of Alprostadil and Spironolactone, by age (0-1 to 60+)? *:

0-1:

Apnoeic attack
Neonatal disorder (disease of neonates)
Blood pressure systolic decreased
Heart rate increased
Infantile apnoeic attack (episodes where breathing stops temporarily in infant)
Neonatal hyponatraemia (low body temperature in neonate)
Apnoea (suspension of external breathing)
Blood potassium increased
Body temperature decreased
Cardiac failure

2-9:

Haematuria (presence of blood in urine)

10-19:

n/a

20-29:

Bone pain
Death

30-39:

Back pain
Blood creatinine increased
Blood urea increased
Blood urine present
C-reactive protein increased
Haemoglobin decreased
Incision site pain
Lymphocyte count decreased
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)

40-49:

Pain in extremity
Anaemia (lack of blood)
Blood glucose increased
Blood urea increased
C-reactive protein increased
Diarrhoea
Incision site haemorrhage (bleeding from incision site)
Incision site pain
Lymphocyte count decreased
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

50-59:

Nasopharyngitis (inflammation of the nasopharynx)
Osteoporosis (bones weak and more likely to break)
Overdose
Protein urine present
Upper respiratory tract infection
Wound complication
Palpitations (feelings or sensations that your heart is pounding or racing)
Pyrexia (fever)
Abdominal distension
Bloody discharge

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nephrogenic anaemia (anaemia due to kidney disease)
Extremity necrosis (death of body tissue of arms and legs)
Iron deficiency anaemia
Peripheral arterial occlusive disease (reproducible ischemic muscle pain)
Peripheral circulatory failure
Anaemia (lack of blood)
Pain in extremity
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Acute myocardial infarction (acute heart attack)

What are the existing conditions these people have? *

High Blood Pressure: 29 people, 34.12%
Urination - Excessive Volume: 20 people, 23.53%
Sedation: 13 people, 15.29%
Productive Cough: 11 people, 12.94%
Constipation: 11 people, 12.94%
Infection: 8 people, 9.41%
Pain: 8 people, 9.41%
Heart Disease: 7 people, 8.24%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 7 people, 8.24%
Electrolyte Imbalance: 7 people, 8.24%

* Approximation only. Some reports may have incomplete information.

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