Ambien cr and Requip drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ambien cr (zolpidem tartrate) and Requip (ropinirole hydrochloride). Common drug interactions include protein urine among females and amnesia among males.

The phase IV clinical study analyzes what interactions people have when they take Ambien cr and Requip. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Ambien cr?

Ambien cr has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 5,660 Ambien cr users. Check the latest studies of Ambien cr.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

On Jul, 04, 2026

78 people who take Ambien cr and Requip together, and have interactions are studied.

What are the common drug interactions of Ambien Cr and Requip, by gender? *:

female:

Protein urine
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Therapeutic response decreased (less preventive response)
Therapeutic response unexpected
Weight increased
Injection site pruritus (severe itching at injection site)
Oedema peripheral (superficial swelling)
Abdominal discomfort

male:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Somnambulism (sleep walking)
Acne (skin problems that cause pimples)
Amyloidosis (a tumour within which amyloid is produced)
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Bladder dysfunction
Blood bilirubin increased
Blood creatinine decreased

What are the common drug interactions of Ambien Cr and Requip, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug ineffective
Suicidal ideation
Abdominal pain upper
Acne (skin problems that cause pimples)
Arthralgia (joint pain)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Ear infection
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pulmonary mycosis (lung infection caused by yeast-like fungi)

40-49:

Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthropathy
Asthenia (weakness)
Bedridden
Blood cholesterol increased
Blood creatinine decreased
Blood magnesium decreased
Blood potassium decreased
Blood pressure increased
Cardiomegaly (increased size of heart than normal)

50-59:

Fall
Injection site pain
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Urinary tract infection
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bladder dysfunction
Drug ineffective
Limb crushing injury (crushing injury of upper limb)
Night sweats (sweating in night)

60+:

Cataract (clouding of the lens inside the eye)
Drug ineffective
Application site swelling
Application site warmth
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Bladder dysfunction
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cardiac disorder
Cardiomyopathy (weakening of the heart muscle)

What are the existing conditions these people have? *

Stress And Anxiety: 21 people, 26.92%
Pain: 18 people, 23.08%
Sleep Disorder: 15 people, 19.23%
Depression: 11 people, 14.10%
Migraine (headache): 10 people, 12.82%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 12.82%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 11.54%
Nausea (feeling of having an urge to vomit): 9 people, 11.54%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 11.54%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 8 people, 10.26%

* Approximation only. Some reports may have incomplete information.

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