Ambien and Trulance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ambien (zolpidem tartrate) and Trulance (plecanatide). Common drug interactions include tubulointerstitial nephritis among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Ambien and Trulance. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

What is Trulance?

Trulance has active ingredients of plecanatide. eHealthMe is studying from 1,746 Trulance users. Check the latest studies of Trulance.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

48 people who take Ambien and Trulance together, and have interactions are studied.

What are the common drug interactions of Ambien and Trulance, by gender? *:

female:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Visual impairment
Wrist fracture
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Decreased appetite
General physical condition
Migraine (headache)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Weight decreased
Abdominal distension

male:

Diarrhoea
Syncope (loss of consciousness with an inability to maintain postural tone)
Testicular pain (pain in testes)
Blood potassium increased
Carbon dioxide increased
Cardiac disorder
Dyspepsia (indigestion)
Electrolyte imbalance
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

What are the common drug interactions of Ambien and Trulance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain upper
Bone pain
Chest discomfort
Dysstasia (difficulty in standing)
Hypoaesthesia (reduced sense of touch or sensation)
Menstrual disorder (disease of menstrual cycle)
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sensory loss (senses loss)

50-59:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Carbon dioxide increased
Hospitalisation

60+:

Diarrhoea
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Vertigo
Fluid retention (an abnormal accumulation of fluid in the blood)
Aphonia (inability to produce voice)
Back pain
Dehydration (dryness resulting from the removal of water)
Herpes zoster
Neuropathy peripheral (surface nerve damage)

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 11 people, 22.92%
Constipation: 8 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 14.58%
Sleep Disorder: 5 people, 10.42%
Immunodeficiency Common Variable: 4 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 6.25%
High Blood Pressure: 3 people, 6.25%
Drowsiness: 3 people, 6.25%
Asthma: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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