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Metformin and Iga nephropathy - a phase IV clinical study of FDA data

Summary:

Iga nephropathy is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 60+ old, also take Furosemide, and have Colorectal cancer metastatic.

The phase IV clinical study analyzes which people have Iga nephropathy when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Iga nephropathy?

Iga nephropathy (kidney disease- condition prevents the kidneys from filtering waste) is found to be associated with 91 drugs and 424 conditions by eHealthMe. Check the latest studies of Iga nephropathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 29 people (0.01%) have Iga nephropathy.

Could Metformin cause Iga nephropathy?

Among these 29 people:

What is the gender of people who have Iga nephropathy when taking Metformin? *

  • female: 35.71 %
  • male: 64.29 %

What is the age of people who have Iga nephropathy when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 3.57 %
  • 30-39: 0.0 %
  • 40-49: 17.86 %
  • 50-59: 25.0 %
  • 60+: 53.57 %

What are other drugs people take besides Metformin? *

  1. Omeprazole: 6 people, 20.69%
  2. Furosemide: 6 people, 20.69%
  3. Lonsurf: 5 people, 17.24%
  4. Apixaban: 4 people, 13.79%
  5. Simvastatin: 3 people, 10.34%
  6. Oxaliplatin: 2 people, 6.90%
  7. Fluorouracil: 2 people, 6.90%
  8. Dabigatran Etexilate Mesylate: 2 people, 6.90%
  9. Nexium: 2 people, 6.90%
  10. Allopurinol: 2 people, 6.90%

What are other side effects people have besides Iga nephropathy? *

  1. Anaemia (lack of blood): 6 people, 20.69%
  2. Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 6 people, 20.69%
  3. Thrombocytopenia (decrease of platelets in blood): 6 people, 20.69%
  4. Weakness: 6 people, 20.69%
  5. Acute Kidney Failure: 4 people, 13.79%
  6. Blood Lactate Dehydrogenase Increased: 4 people, 13.79%
  7. Renal Tubular Necrosis (death of kidney tubules): 2 people, 6.90%
  8. Henoch-Schonlein Purpura (inflammation of the blood vessels in the skin and other body organs): 2 people, 6.90%
  9. Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 2 people, 6.90%
  10. Nephritis (inflammation of the nephrons in the kidneys): 2 people, 6.90%

What are the existing conditions these people have? *

  1. Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 5 people, 17.24%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 13.79%
  3. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 4 people, 13.79%
  4. High Blood Pressure: 3 people, 10.34%
  5. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 10.34%
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.90%
  7. Hepatocellular Carcinoma (liver cancer): 2 people, 6.90%
  8. High Blood Cholesterol: 1 person, 3.45%
  9. Renal Cancer Metastatic (cancer of kidney spreads to other part): 1 person, 3.45%
  10. Joint Swelling: 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Iga nephropathy?

- Check whether Iga nephropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Iga nephropathy treatments and more:

How severe was Iga nephropathy and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Iga nephropathy:

Browse all the conditions that are associated with Iga nephropathy:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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