Amerge and Plaquenil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amerge (naratriptan hydrochloride) and Plaquenil (hydroxychloroquine sulfate). Common drug interactions include neck pain among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Amerge and Plaquenil. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Amerge?

Amerge has active ingredients of naratriptan hydrochloride. It is often used in migraine. eHealthMe is studying from 1,470 Amerge users. Check the latest studies of Amerge.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.

On Jul, 12, 2026

11 people who take Amerge and Plaquenil together, and have interactions are studied.

What are the common drug interactions of Amerge and Plaquenil, by gender? *:

female:

Neck pain
Infusion site infection
Abdominal pain
Abdominal tenderness
Abnormal behaviour
Activities of daily living impaired
Adverse reaction
Affective disorder (mental disorder)
Alcoholism (problems with alcohol)
Alopecia (absence of hair from areas of the body)

male:

Arthralgia (joint pain)
Malaise (a feeling of general discomfort or uneasiness)
Pulmonary embolism (blockage of the main artery of the lung)
Cerebral haemorrhage (bleeding within the brain)
Drug ineffective

What are the common drug interactions of Amerge and Plaquenil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Insomnia (sleeplessness)
Irritability
Irritable bowel syndrome
Lacrimation increased
Lethargy (tiredness)
Leukopenia (less number of white blood cells in blood)
Lip ulceration (ulcer of lip)
Loss of consciousness
Lupus encephalitis (a chronic inflammatory autoimmune disorder that may affect brain)
Lupus enteritis (a chronic inflammatory autoimmune disorder that may affect intestines)

40-49:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

50-59:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haematuria (presence of blood in urine)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Malaise (a feeling of general discomfort or uneasiness)
Nephrolithiasis (calculi in the kidneys)
Pancreatitis (inflammation of pancreas)
Pulmonary embolism (blockage of the main artery of the lung)
Retroperitoneal haemorrhage (bleeding between the peritoneum and the posterior abdominal wall)
Abdominal distension
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

60+:

Arthralgia (joint pain)
Malaise (a feeling of general discomfort or uneasiness)
Pulmonary embolism (blockage of the main artery of the lung)
Cerebral haemorrhage (bleeding within the brain)
Drug ineffective

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 27.27%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 9.09%
Cardiac Disorder: 1 person, 9.09%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 9.09%
Depression: 1 person, 9.09%
Diabetes: 1 person, 9.09%
Drowsiness: 1 person, 9.09%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 9.09%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 9.09%
Gastric Disorder (disease of stomach): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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