Amicar and Cytoxan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amicar (aminocaproic acid) and Cytoxan (cyclophosphamide). Common drug interactions include arthralgia among females and cytokine release syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Amicar and Cytoxan. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Amicar?

Amicar has active ingredients of aminocaproic acid. eHealthMe is studying from 1,323 Amicar users. Check the latest studies of Amicar.

What is Cytoxan?

Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.

On Jul, 14, 2026

18 people who take Amicar and Cytoxan together, and have interactions are studied.

What are the common drug interactions of Amicar and Cytoxan, by gender? *:

female:

Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cataract (clouding of the lens inside the eye)
Contusion (a type of hematoma of tissue in which capillaries)
Cytomegalovirus infection
Diarrhoea
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Epistaxis (bleed from the nose)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)

male:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoxia (low oxygen in tissues)
Ascites (accumulation of fluid in the abdominal cavity)
Atelectasis (partial or complete collapse of the lung)
Blood creatinine increased
Blood urea increased
Chest discomfort
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Coagulopathy (blood's ability to clot is impaired)
Confusional state

What are the common drug interactions of Amicar and Cytoxan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Lung infection
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Blood lactic acid increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)
Hyperkalaemia (damage to or disease of the kidney)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)

20-29:

n/a

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Disease progression
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Transplant rejection (a transplant material is not worked)

40-49:

Leukaemia recurrent (repeat cancer of bone marrow or blood cells)
Vaginal haemorrhage (vaginal bleeding)
Hypercalcaemia (elevated calcium (ca+) level in the blood)

50-59:

Bacteraemia (presence of bacteria in the blood)
Bone disorder
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Infection
Liver disorder (liver diseases)
Loss of consciousness
Purulent discharge (discharge that contains pus)
Skin disorder (skin disease)

60+:

n/a

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 27.78%
Anaemia Of Malignant Disease: 3 people, 16.67%
Pain: 2 people, 11.11%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 2 people, 11.11%
Constipation: 2 people, 11.11%
Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 11.11%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.56%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 5.56%
Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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