Amitiza and Pataday drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitiza (lubiprostone) and Pataday (olopatadine hydrochloride). Common drug interactions include peripheral swelling among females and gastroenteritis viral among males.

The phase IV clinical study analyzes what interactions people have when they take Amitiza and Pataday. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Pataday?

Pataday has active ingredients of olopatadine hydrochloride. It is often used in allergies. eHealthMe is studying from 8,288 Pataday users. Check the latest studies of Pataday.

On Aug, 13, 2026

40 people who take Amitiza and Pataday together, and have interactions are studied.

What are the common drug interactions of Amitiza and Pataday, by gender? *:

female:

Peripheral swelling
Plantar fasciitis (painful inflammatory process of the plantar fascia)
Rash
Renal injury (kidney injury)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Sinus disorder (disease of sinus)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Surgery
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Uterine prolapse

male:

Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Pain
Aphasia (damage to the parts of the brain that control language)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Back pain
Balance disorder
Bone density decreased
Chronic kidney disease

What are the common drug interactions of Amitiza and Pataday, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Chronic kidney disease
Depressed mood
Emotional distress
Irritability
Malaise (a feeling of general discomfort or uneasiness)
Weight increased

40-49:

Chronic kidney disease
Alopecia (absence of hair from areas of the body)
Bladder prolapse (bulging of one or more of the pelvic organs into the vagina)
Dizziness
Fatigue (feeling of tiredness)
Feeling jittery
Limb injury
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Tendon rupture (tear of tendon)
Headache (pain in head)
Weight increased
Pruritus (severe itching of the skin)
Pruritus generalised (generalized itching)
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Decreased appetite
Pain

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Alopecia (absence of hair from areas of the body)
Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)
Asthenia (weakness)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Back pain
Balance disorder
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 32.50%
Pain: 12 people, 30.00%
High Blood Pressure: 11 people, 27.50%
Hypersensitivity: 10 people, 25.00%
Stress And Anxiety: 10 people, 25.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 25.00%
Asthma: 9 people, 22.50%
Infection: 9 people, 22.50%
Depression: 9 people, 22.50%
High Blood Cholesterol: 8 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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