Amitiza and Tamsulosin hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitiza (lubiprostone) and Tamsulosin hydrochloride (tamsulosin hydrochloride). Common drug interactions include eye pain among females and adrenal insufficiency among males.

The phase IV clinical study analyzes what interactions people have when they take Amitiza and Tamsulosin hydrochloride. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

What is Tamsulosin hydrochloride?

Tamsulosin hydrochloride has active ingredients of tamsulosin hydrochloride. It is often used in prostate examination abnormal. eHealthMe is studying from 18,329 Tamsulosin hydrochloride users. Check the latest studies of Tamsulosin hydrochloride.

On Jul, 15, 2026

56 people who take Amitiza and Tamsulosin hydrochloride together, and have interactions are studied.

Amitiza and Tamsulosin hydrochloride drug interactions.

What are the common drug interactions of Amitiza and Tamsulosin Hydrochloride, by gender? *:

female:

Eye pain
Eye pruritus (eye itching)
Fatigue (feeling of tiredness)
Feeling hot
Gamma-glutamyltransferase increased
Generalised erythema (redness of the skin all over the body)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Iron deficiency anaemia
Lacrimation increased

male:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Gastrointestinal mucosal necrosis (damage of mucous membrane in gastrointestinal tract)
Injection site swelling
Orchitis (inflammation of the testes)
Platelet count decreased
Sinusitis (inflammation of sinus)
Prostate infection
Drug eruption (adverse drug reaction of the skin)
Liver disorder (liver diseases)
Cancer pain

What are the common drug interactions of Amitiza and Tamsulosin Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dyspnoea exertional (breathlessness or shortness of breath)
Eye pain
Eye pruritus (eye itching)
Feeling hot
Generalised erythema (redness of the skin all over the body)
Lacrimation increased
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Oropharyngeal pain
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)

40-49:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Asthma
Blood sodium decreased
Blood uric acid decreased
Fatigue (feeling of tiredness)
Gamma-glutamyltransferase increased
Rash

50-59:

Headache (pain in head)
Weight increased

60+:

Gastrointestinal mucosal necrosis (damage of mucous membrane in gastrointestinal tract)
Pneumonia
Eosinophil count increased
Haemoglobin decreased
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
White blood cell count decreased
Decreased appetite
Depression
Insomnia (sleeplessness)

What are the existing conditions these people have? *

High Blood Pressure: 9 people, 16.07%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 16.07%
Metastases To Bone (cancer spreads to bone): 9 people, 16.07%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 7 people, 12.50%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 7 people, 12.50%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 8.93%
Diabetes: 5 people, 8.93%
High Blood Cholesterol: 5 people, 8.93%
Immunodeficiency Common Variable: 5 people, 8.93%
Pain: 5 people, 8.93%

* Approximation only. Some reports may have incomplete information.

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