Zanaflex and Pramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zanaflex (tizanidine hydrochloride) and Pramine (imipramine hydrochloride). Common drug interactions include drug dependence among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Zanaflex and Pramine. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

On Jul, 15, 2026

58 people who take Zanaflex and Pramine together, and have interactions are studied.

What are the common drug interactions of Zanaflex and Pramine, by gender? *:

female:

Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Malaise (a feeling of general discomfort or uneasiness)
Obesity (having too much body fat)
Urinary tract infection
Vision blurred
Back pain
Chest pain
Gait disturbance
Injection site pain

male:

Depression
Abdominal distension
Joint lock
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Non-small cell lung cancer (type of epithelial lung cancer)
Oedema peripheral (superficial swelling)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Adhesion
Aggression
Anaemia (lack of blood)

What are the common drug interactions of Zanaflex and Pramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Drug abuser
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Emotional distress
Fall
Fatigue (feeling of tiredness)
Feeling hot and cold
Headache (pain in head)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bacterial infection
Bladder spasm
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Device related infection
Discomfort
Dysgeusia (disorder of the sense of taste)
Emotional distress
Injury

40-49:

Abdominal pain
Clostridial infection (infectious conditions by clostridium bacteria)
Depression
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Obesity (having too much body fat)
Oedema peripheral (superficial swelling)
Urinary tract infection
Abdominal distension
Back pain

50-59:

Memory impairment
Migraine (headache)
Multiple fractures
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Obesity (having too much body fat)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Oesophageal spasm (contraction of oesophagus)
Osteomyelitis (infection of bone)

60+:

Injection site pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Accident
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Ankle fracture
Back pain
Blood cholesterol increased
Blood sodium decreased
Blood urea increased

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 18.97%
Stress And Anxiety: 6 people, 10.34%
Pain: 6 people, 10.34%
Hyperkalemia (damage to or disease of the kidney): 5 people, 8.62%

* Approximation only. Some reports may have incomplete information.

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