Amitriptyline hydrochloride and Adderall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include regurgitation among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Adderall. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,226 Adderall users. Check the latest studies of Adderall.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

100 people who take Amitriptyline hydrochloride and Adderall together, and have interactions are studied.

Amitriptyline hydrochloride and Adderall drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Adderall, by gender? *:

female:

Regurgitation (expulsion of material)
Splenomegaly (enlargement of spleen)
Swelling
Upper respiratory tract infection
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urinary tract infection
Weight increased
Abscess oral (abscess in the mouth)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)

male:

Asthenia (weakness)
Agitation (state of anxiety or nervous excitement)
Blood cholesterol increased
Foot deformity (functional disability of foot)
Hyperlipidaemia (presence of excess lipids in the blood)
Irritable bowel syndrome
Affect lability (emotional incontinence)
Anxiety
Dizziness
Hallucination (an experience involving the perception of something not present)

What are the common drug interactions of Amitriptyline Hydrochloride and Adderall, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Regurgitation (expulsion of material)
Splenomegaly (enlargement of spleen)
Vomiting
Weight decreased

20-29:

Anxiety
Depressed mood
Fatigue (feeling of tiredness)
Impaired gastric emptying
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Suicidal ideation
Blindness
Gastric disorder (disease of stomach)
Joint injury
Malaise (a feeling of general discomfort or uneasiness)

30-39:

Muscle spasms (muscle contraction)
Suicidal ideation
Drug ineffective
Premenstrual dysphoric disorder
Restless legs syndrome (a powerful urge to move your legs)
Cough
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Fatigue (feeling of tiredness)
Feeling jittery
Hypermobility syndrome (abnormalities cause abnormal stress on a joint or many joint)

40-49:

Pyrexia (fever)
Rash
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Secretion discharge
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress
Suicidal ideation
Tremor (trembling or shaking movements in one or more parts of your body)
Upper respiratory tract congestion

50-59:

Hereditary angioedema (recurrent episodes of severe swelling)
Drug ineffective
Psychotic disorder
Stress
Abdominal pain upper
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anger
Asthenia (weakness)
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Concussion (short loss of normal brain function in response to a head injury)

60+:

Abdominal discomfort
Diarrhoea
Hospitalisation
Hot flush (sudden feelings of heat)
Menopause (end of monthly cycles in women)
Nasopharyngitis (inflammation of the nasopharynx)
Anxiety
Asthenia (weakness)
Blood pressure increased
Coeliac disease (simple food intolerance)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 51 people, 51.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 41 people, 41.00%
Drowsiness: 27 people, 27.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 11.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 8.00%
Insomnia (sleeplessness): 6 people, 6.00%
Pain: 5 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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