Amitriptyline hydrochloride and Levothroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Levothroid (levothyroxine sodium). Common drug interactions include renal disorder among females and abdominal adhesions among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Levothroid. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

On Jul, 16, 2026

26 people who take Amitriptyline hydrochloride and Levothroid together, and have interactions are studied.

Amitriptyline hydrochloride and Levothroid drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Levothroid, by gender? *:

female:

Renal disorder (kidney disease)
Vertigo
Abdominal adhesions (inflammation of abdomen)
Abdominal pain upper
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Ankle fracture
Aortic calcification (aortic calcification sign of heart valve disease)
Arthralgia (joint pain)

male:

Abdominal adhesions (inflammation of abdomen)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Attention deficit/hyperactivity disorder
Autonomic failure syndrome (a degenerative disease of the autonomic nervous system)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Blood glucose fluctuation
Cardiolipin antibody positive
Cerebellar ataxia (loss of coordination)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Amitriptyline Hydrochloride and Levothroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asphyxia (a condition in which there is an extreme decrease in the concentration of oxygen in the body)
Cerebral oedema (swelling of brain)
Drug effect decreased
Eye oedema (swelling or thickening of the macula, the area of the retina responsible for central vision)
Overdose
Pulmonary congestion (congestion in the lungs)
Pulmonary oedema (fluid accumulation in the lungs)

30-39:

n/a

40-49:

Drug eruption (adverse drug reaction of the skin)
Drug ineffective
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight decreased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Arrhythmia (irregular heartbeat)
Hypotension (abnormally low blood pressure)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

50-59:

Joint swelling
Weight increased
Mitral valve prolapse (heart's mitral valve doesn't work well)
Weight decreased
Anaemia (lack of blood)
Aortic calcification (aortic calcification sign of heart valve disease)
Arthralgia (joint pain)
Asthenia (weakness)
Asthma
Atelectasis (partial or complete collapse of the lung)

60+:

Asthenia (weakness)
Cough
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ankle fracture
Anxiety
Aphonia (inability to produce voice)
Arrhythmia (irregular heartbeat)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthma
Attention deficit/hyperactivity disorder

What are the existing conditions these people have? *

Depression: 8 people, 30.77%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 26.92%
Osteoporosis (bones weak and more likely to break): 7 people, 26.92%
Thyroid Diseases: 6 people, 23.08%
Stable Angina (a constant chest pain): 6 people, 23.08%
Sleep Disorder: 6 people, 23.08%
Panic Disorder: 6 people, 23.08%
Cardiac Failure Congestive: 6 people, 23.08%
Arrhythmias (irregular heartbeat): 6 people, 23.08%
Impaired Gastric Emptying: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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