Amitriptyline hydrochloride and Provera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Provera (medroxyprogesterone acetate). Common drug interactions include renal disorder among females and abdominal adhesions among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Provera. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

On Jul, 10, 2026

53 people who take Amitriptyline hydrochloride and Provera together, and have interactions are studied.

Amitriptyline hydrochloride and Provera drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Provera, by gender? *:

female:

Renal disorder (kidney disease)
Abdominal adhesions (inflammation of abdomen)
Abdominal pain
Abdominal pain lower
Activities of daily living impaired
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ankle fracture
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anuria (failure of the kidneys to produce urine)

male:

Abdominal adhesions (inflammation of abdomen)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Attention deficit/hyperactivity disorder
Autonomic failure syndrome (a degenerative disease of the autonomic nervous system)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Blood glucose fluctuation
Cardiolipin antibody positive
Cerebellar ataxia (loss of coordination)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Amitriptyline Hydrochloride and Provera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Nausea (feeling of having an urge to vomit)
Vomiting

20-29:

Activities of daily living impaired
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fatigue (feeling of tiredness)
Foot fracture
Hot flush (sudden feelings of heat)
Localised oedema (fluid retention in a particular part of the body)
Rash macular (small, flat red spots)

30-39:

Abdominal pain
Chills (felling of cold)
Device dislocation
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Infusion site discomfort
Infusion site erythema (reddening of the skin at infusion site)
Infusion site induration
Infusion site irritation
Infusion site pain

40-49:

Alopecia (absence of hair from areas of the body)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)
Myasthenic syndrome (a group of conditions characterized by muscle weakness (myasthenia) that worsens with physical exertion)
Nausea (feeling of having an urge to vomit)
Vaginal haemorrhage (vaginal bleeding)

50-59:

Anaemia (lack of blood)
Asthma
Influenza
Kidney fibrosis (excess fibrous connective tissue in kidney)
Nephrocalcinosis (a condition in which calcium levels in the kidneys are increased)
Renal failure chronic (long lasting kidney dysfunction)
Breast cancer female
Arthralgia (joint pain)
Breast cancer
Pain in extremity

60+:

Breast cancer female
Constipation
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Ankle fracture
Anuria (failure of the kidneys to produce urine)
Anxiety
Aphonia (inability to produce voice)
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 11.32%
Immunodeficiency Common Variable: 5 people, 9.43%
Drowsiness: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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