Amitriptyline hydrochloride and Tylenol w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amitriptyline hydrochloride (amitriptyline hydrochloride) and Tylenol w/ codeine (acetaminophen; codeine phosphate). Common drug interactions include lumbar spinal stenosis among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Amitriptyline hydrochloride and Tylenol w/ codeine. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Amitriptyline hydrochloride?

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 20,054 Amitriptyline hydrochloride users. Check the latest studies of Amitriptyline hydrochloride.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

14 people who take Amitriptyline hydrochloride and Tylenol w/ codeine together, and have interactions are studied.

Amitriptyline hydrochloride and Tylenol w/ codeine drug interactions.

What are the common drug interactions of Amitriptyline Hydrochloride and Tylenol W/ Codeine, by gender? *:

female:

Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Malaise (a feeling of general discomfort or uneasiness)
Mastication disorder (disease of chewing food)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Methicillin-resistant staphylococcal aureus infection
Monoclonal immunoglobulin present
Multiple myeloma (cancer of the plasma cells)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

male:

Abdominal pain
Dissociative disorder
Hyperacidity
Hyperchlorhydria (gastric acid levels are higher in stomach)
Pyloric stenosis (narrowing of the passage between the stomach and the small intestine)
Pyloric ulcer (peptic ulcer)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Gastrointestinal ulcer
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)

What are the common drug interactions of Amitriptyline Hydrochloride and Tylenol W/ Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

20-29:

n/a

30-39:

Completed suicide (act of taking one's own life)
Methicillin-resistant staphylococcal aureus infection
Post-operative wound infection

40-49:

Abdominal pain
Dissociative disorder
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Gastrointestinal ulcer
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Weight increased
Application site reaction
Hyperacidity

50-59:

Nervousness
Neuropathy peripheral (surface nerve damage)
Night sweats (sweating in night)
Obesity (having too much body fat)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Onychomycosis (fungal infection of the nail)
Oral pain
Osteitis (a general term for inflammation of bone)
Osteonecrosis of jaw (death of bone of jaw)

60+:

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Headache (pain in head)
Aggression
Confusional state
Hallucination (an experience involving the perception of something not present)
Hypertension (high blood pressure)
Infection
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Subdural haematoma (blood collects between the skull and the surface of the brain)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 28.57%
Depression: 2 people, 14.29%
Stress And Anxiety: 1 person, 7.14%
Neoplasm Malignant (cancer tumour): 1 person, 7.14%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 7.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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