Amlodipine and Glucotrol xl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amlodipine (amlodipine besylate) and Glucotrol xl (glipizide). Common drug interactions include hepatitis a antibody positive among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Amlodipine and Glucotrol xl. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Amlodipine?

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 354,829 Amlodipine users. Check the latest studies of Amlodipine.

What is Glucotrol xl?

Glucotrol xl has active ingredients of glipizide. It is often used in diabetes. eHealthMe is studying from 6,863 Glucotrol xl users. Check the latest studies of Glucotrol xl.

On Jul, 20, 2026

77 people who take Amlodipine and Glucotrol xl together, and have interactions are studied.

Amlodipine and Glucotrol xl drug interactions.

What are the common drug interactions of Amlodipine and Glucotrol Xl, by gender? *:

female:

Hepatitis a antibody positive
Leg ulcer (exc varicose) (leg ulcer without varicose vein)
Pyrexia (fever)
Renal failure (kidney dysfunction)
Weakness
Respiratory failure (inadequate gas exchange by the respiratory system)
Blood culture positive
Blood urea increased
Constipation
Drug ineffective

male:

Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Localised infection (infection at the single location)
Nausea (feeling of having an urge to vomit)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Back disorder
Back pain

What are the common drug interactions of Amlodipine and Glucotrol Xl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Depression
Emotional distress
Pain
Renal failure (kidney dysfunction)
Diabetes mellitus inadequate control
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Fatigue (feeling of tiredness)

50-59:

Bipolar disorder (mood disorder)
Depression
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Feeling hot
Flushing (the warm, red condition of human skin)
Hypoaesthesia (reduced sense of touch or sensation)
Laryngospasm (an uncontrolled/involuntary muscular contraction of larynx)
Ocular vascular disorder (disease of eye blood circulation)

60+:

Malaise (a feeling of general discomfort or uneasiness)
Oedema lower limb (fluid collection in tissue of lower leg)
Drug ineffective
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)

What are the existing conditions these people have? *

Pain: 11 people, 14.29%
High Blood Cholesterol: 8 people, 10.39%
Nausea (feeling of having an urge to vomit): 6 people, 7.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.79%
Type 2 Diabetes: 5 people, 6.49%
Toxic Neuropathy (nerve damage caused by toxic (harmful) substances): 5 people, 6.49%
Neuropathy Peripheral (surface nerve damage): 5 people, 6.49%
Insomnia (sleeplessness): 5 people, 6.49%
Inflammation: 5 people, 6.49%
Hypersensitivity: 5 people, 6.49%

* Approximation only. Some reports may have incomplete information.

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