Amlodipine and Levonorgestrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amlodipine (amlodipine besylate) and Levonorgestrel (levonorgestrel). Common drug interactions include posterior reversible encephalopathy syndrome among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Amlodipine and Levonorgestrel. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Amlodipine?

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 354,830 Amlodipine users. Check the latest studies of Amlodipine.

What is Levonorgestrel?

Levonorgestrel has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 4,186 Levonorgestrel users. Check the latest studies of Levonorgestrel.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

36 people who take Amlodipine and Levonorgestrel together, and have interactions are studied.

Amlodipine and Levonorgestrel drug interactions.

What are the common drug interactions of Amlodipine and Levonorgestrel, by gender? *:

female:

Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Scleroderma (hard skin)
Skin injury
Stress
Tongue oedema (swelling of tongue)
Tremor (trembling or shaking movements in one or more parts of your body)
Vitamin d deficiency
Fatigue (feeling of tiredness)
Diarrhoea
Dizziness

male:

Fatigue (feeling of tiredness)
Diarrhoea
Muscle spasms (muscle contraction)
Nail injury
Night sweats (sweating in night)
Pain in extremity
Pyrexia (fever)
Rash pruritic (redness with itching)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Tinea pedis (a contagious skin infection caused by the ringworm fungus)

What are the common drug interactions of Amlodipine and Levonorgestrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Death
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Blindness
Balance disorder
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Drug hypersensitivity
Herpes zoster
Nausea (feeling of having an urge to vomit)

40-49:

Dizziness
Fatigue (feeling of tiredness)
Age-related macular degeneration
Blindness
Influenza
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Nausea (feeling of having an urge to vomit)
Vomiting
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

50-59:

Diarrhoea
Fatigue (feeling of tiredness)
Muscle spasms (muscle contraction)
Nail injury
Night sweats (sweating in night)
Pain in extremity
Pyrexia (fever)
Rash pruritic (redness with itching)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Tinea pedis (a contagious skin infection caused by the ringworm fungus)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 30.56%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 22.22%
Pain: 5 people, 13.89%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 13.89%
Drowsiness: 4 people, 11.11%
Diarrhea: 4 people, 11.11%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 8.33%
Malignant Melanoma (skin cancer rises from melancytes): 3 people, 8.33%
Irritability: 3 people, 8.33%
Inflammation: 3 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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