Ampyra and Compazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ampyra (dalfampridine) and Compazine (prochlorperazine maleate). Common drug interactions include discomfort among females and aphasia among males.

The phase IV clinical study analyzes what interactions people have when they take Ampyra and Compazine. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Ampyra?

Ampyra has active ingredients of dalfampridine. It is often used in multiple sclerosis. eHealthMe is studying from 77,145 Ampyra users. Check the latest studies of Ampyra.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in indigestion. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

On Jul, 27, 2026

52 people who take Ampyra and Compazine together, and have interactions are studied.

What are the common drug interactions of Ampyra and Compazine, by gender? *:

female:

Discomfort
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dysarthria (speech disorder)
Emotional distress
Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)
Endometrial atrophy
Endometrial disorder
Flatulence (flatus expelled through the anus)
General physical health deterioration (weak health status)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

male:

Aphasia (damage to the parts of the brain that control language)
Neuropathy peripheral (surface nerve damage)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Hypoaesthesia (reduced sense of touch or sensation)
Influenza like illness
Memory impairment
Mobility decreased (ability to move is reduced)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Photopsia (presence of perceived flashes of light)
Temperature intolerance (inability to go in temperature)

What are the common drug interactions of Ampyra and Compazine, by age (0-1 to 60+)? *:

0-1:

Cardiac murmur (an heart sound in valve abnormality)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Premature baby

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood pressure increased
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Glucose tolerance impaired in pregnancy (higher glucose level in pregnancy but not diabetes)
Headache (pain in head)
Maternal exposure during pregnancy (use of substance during pregnancy)
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
Premature labour
Swelling
Breast cancer stage ii

40-49:

Fall
Breast cancer metastatic
Gait disturbance
Anxiety
Memory impairment
Pain
Pneumonia
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)

50-59:

Deformity (disfigurement)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Emotional distress
Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)
Endometrial atrophy
Endometrial disorder
Erythema (redness of the skin)
Fatigue (feeling of tiredness)

60+:

Pneumonia
Dysphonia (speech disorder attributable to a disorder of phonation)
Gait disturbance
Balance disorder
Infection
Dehydration (dryness resulting from the removal of water)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pain
Urinary tract infection
Acute respiratory failure

What are the existing conditions these people have? *

Gait Disturbance: 12 people, 23.08%
Stress And Anxiety: 6 people, 11.54%
Pain: 6 people, 11.54%
Injection Site Pain: 5 people, 9.62%
Asthma: 5 people, 9.62%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 7.69%
Nausea (feeling of having an urge to vomit): 4 people, 7.69%
Migraine (headache): 3 people, 5.77%
Iron Deficiency: 3 people, 5.77%
Headache (pain in head): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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