Amrix and Kadian drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amrix (cyclobenzaprine hydrochloride) and Kadian (morphine sulfate). Common drug interactions include chronic kidney disease among females and sinusitis among males.

The phase IV clinical study analyzes what interactions people have when they take Amrix and Kadian. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Amrix?

Amrix has active ingredients of cyclobenzaprine hydrochloride. It is often used in back pain. eHealthMe is studying from 1,130 Amrix users. Check the latest studies of Amrix.

What is Kadian?

Kadian has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 23,045 Kadian users. Check the latest studies of Kadian.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

14 people who take Amrix and Kadian together, and have interactions are studied.

What are the common drug interactions of Amrix and Kadian, by gender? *:

female:

Chronic kidney disease

male:

Sinusitis (inflammation of sinus)
Eye pain
Anger
Appetite disorder (abnormal eating habits)
Confusional state
Depression
Dizziness
Drug effect decreased
Intervertebral disc injury (spinal disc injury)
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Amrix and Kadian, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease

60+:

Eye pain
Joint swelling
Anger
Appetite disorder (abnormal eating habits)
Confusional state
Depression
Dizziness
Drug effect decreased
Intervertebral disc injury (spinal disc injury)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Depression: 8 people, 57.14%
High Blood Cholesterol: 7 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 50.00%
Muscle Spasms (muscle contraction): 7 people, 50.00%
Headache (pain in head): 5 people, 35.71%
Stress And Anxiety: 5 people, 35.71%
Constipation: 4 people, 28.57%
Hypersensitivity: 4 people, 28.57%
Muscle Aches (muscle pain): 4 people, 28.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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