Amrix and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Amrix (cyclobenzaprine hydrochloride) and Nucynta (tapentadol hydrochloride). Common drug interactions include gait disturbance among females.

The phase IV clinical study analyzes what interactions people have when they take Amrix and Nucynta. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Amrix?

Amrix has active ingredients of cyclobenzaprine hydrochloride. It is often used in back pain. eHealthMe is studying from 1,130 Amrix users. Check the latest studies of Amrix.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Jul, 16, 2026

29 people who take Amrix and Nucynta together, and have interactions are studied.

What are the common drug interactions of Amrix and Nucynta, by gender? *:

female:

Gait disturbance
Neuralgia (pain in one or more nerves)
Fungal infection
Gastric ulcer (stomach ulcer)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Adverse event
Abdominal rigidity
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

male:

n/a

What are the common drug interactions of Amrix and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Application site erythema (redness of the skin at application site)
Application site rash
Drug ineffective
Fungal infection
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Adverse event
Ill-defined disorder
Abdominal pain upper
Angioedema (rapid swelling of the dermis)

50-59:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Abdominal rigidity
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chest pain
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrointestinal infection (infection of stomach and intestine)
Nausea (feeling of having an urge to vomit)
Oesophageal spasm (contraction of oesophagus)
Rotator cuff repair

60+:

Drug screen positive
Ankle fracture
Hyperhidrosis (abnormally increased sweating)
Oral herpes (viral infection of mouth)
Therapeutic response unexpected

What are the existing conditions these people have? *

Breakthrough Pain: 8 people, 27.59%
Sleep Disorder: 7 people, 24.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 24.14%
Osteoporosis (bones weak and more likely to break): 6 people, 20.69%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 20.69%
Insomnia (sleeplessness): 5 people, 17.24%
High Blood Cholesterol: 5 people, 17.24%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 17.24%
Migraine (headache): 4 people, 13.79%
Neuralgia (pain in one or more nerves): 3 people, 10.34%

* Approximation only. Some reports may have incomplete information.

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