Anafranil and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Anafranil (clomipramine hydrochloride) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include abdominal discomfort among females and alcohol interaction among males.

The phase IV clinical study analyzes what interactions people have when they take Anafranil and Hydroxyzine. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Anafranil?

Anafranil has active ingredients of clomipramine hydrochloride. It is often used in obsessive-compulsive disorder. eHealthMe is studying from 6,304 Anafranil users. Check the latest studies of Anafranil.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 21, 2026

33 people who take Anafranil and Hydroxyzine together, and have interactions are studied.

Anafranil and Hydroxyzine drug interactions.

What are the common drug interactions of Anafranil and Hydroxyzine, by gender? *:

female:

Abdominal discomfort
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Restless legs syndrome (a powerful urge to move your legs)
Somnambulism (sleep walking)
Ankle fracture
Electrocardiogram qt prolonged
Fall
Hypotension (abnormally low blood pressure)
Suicidal ideation
Tonic clonic movements (generalized seizure that affects the entire brain)

male:

Alcohol interaction
Bipolar disorder (mood disorder)
Schizoaffective disorder (a mental disorder characterized by disordered thought)
Seasonal affective disorder (a type of depression that occurs at a certain time of the year, usually in the winter)
Self esteem decreased (self worth reduced)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Atrioventricular block (heart block)
Bradycardia (abnormally slow heart action)
Cardiac arrest
Completed suicide (act of taking one's own life)

What are the common drug interactions of Anafranil and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Atrioventricular block (heart block)
Blood pressure decreased
Bradycardia (abnormally slow heart action)
Cardiac arrest
Completed suicide (act of taking one's own life)
Dyspnoea (difficult or laboured respiration)
Eating disorder
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
General physical health deterioration (weak health status)

30-39:

Alcohol interaction
Bipolar disorder (mood disorder)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Delusion (a false belief or opinion)
Hallucination (an experience involving the perception of something not present)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Loss of consciousness
Mania (a state of abnormally elevated or irritable mood)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

40-49:

n/a

50-59:

Abdominal discomfort
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Restless legs syndrome (a powerful urge to move your legs)
Somnambulism (sleep walking)
Arthropathy
Biliary tract infection
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholecystitis (infection of gallbladder)
Hypophagia (reduced food intake)
Pancreatitis (inflammation of pancreas)

60+:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Memory impairment
Renal failure acute (rapid kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Neuralgia (pain in one or more nerves)
Neuropathy peripheral (surface nerve damage)
Restlessness (not able to rest)
Rosacea (a skin condition that causes facial redness)
Suicidal ideation
Anuria (failure of the kidneys to produce urine)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 42.42%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 42.42%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 7 people, 21.21%
High Blood Pressure: 7 people, 21.21%
Pain: 6 people, 18.18%
Depression: 5 people, 15.15%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 12.12%
Post-Traumatic Stress Disorder: 2 people, 6.06%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 2 people, 6.06%
Fatigue (feeling of tiredness): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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